复方苦参注射液联合化疗治疗晚期非小细胞肺癌临床观察

目的了解68例晚期非小细胞肺癌采用单纯VVP方案静脉治疗和复方苦参注射液联合VVP方案治疗的近期疗效、生活质量、毒副反应等.方法随机分为治疗组(复方苦参注射液联合VVP方案组)36例,对照组(单纯VVP方案组)32例,记录观察近期疗效、毒副反应、生活质量变化.结果治疗组总有效率47.22%,止痛总有效率55.6%;对照组总有效率21.88%,止痛总有效率31.25%.两组总有效率差异显著(P＜0.05).治疗组恶心呕吐、口腔炎、转氨酶升高的发生率低于对照组;对照组化疗后与化疗前相比,白细胞下降明显;治疗组化疗前后白细胞下降不明显.治疗组在化疗后Kps评分稍降低,但无明显差异(P＞0.05),而对照组治疗后评分降低,且有明显差异(P＜0.05).结论复方苦参注射液联合化疗治疗晚期非小细胞肺癌明显提高有效率,确能减低药物毒性,提高患者生活质量.

Clinical observation on compound matrine injection combined with chemotherapy in treatment of advanced non-small cell lung cancer

Objective: To investigate the short-term curative effect ,life quality, side-effects and so on of compound matrine injection combined with chemotherapy (VVP), which was applied to treat advanced non-small cellular lung cancer in 68 cases. Methods: 68 patients were divided randomly into treatment group(compound matrine injection combined with VVP, 36 cases ) and control group (VVP, 32 cases). The short-term therapeutic effect, side effects and life quality of all the patients were recorded. Results: The total efficacy in treatment group was 47.22%, the total pain-relieving rate 55.6%. In contrast, The total effective rate of control group was 21.88% and the total pain-relieving rate 31.25%. The total effective rate of two groups is significantly different (P <0.05). Nausea, vomit, stomatitis and transaminases increase in treatment group were lower than those of control group.In control group, leukocyte decreased obviously after chemotherapy, wheras not in treatment group. KPS score in treatment group decreased lightly, there was no obvious difference (P >0.05). However, KPS score decreaed obviously with significant difference (P <0.05). Conclusions: Compound matrine injection in combination with chemotherapy can improve the efficacy and life quality obviously and reduce medical toxicity in treatment of the advanced non-small cell lung cancer.