2型糖尿病家系非糖尿病一级亲属代谢综合征及相关组分患病率的临床研究

目的 了解T2DM家系中非糖尿病一级亲属MS及主要组分的患病率. 方法 选取恩施地区符合条件的128个土家族T2DM家系行OGTT,去除家系组中二级亲属、配偶组中有糖尿病家族史和T2DM患者,将剩余成员分为T2DM组322例、非糖尿病一级亲属（FDR）组298例和非糖尿病且无糖尿病家族史的配偶（NC）组102名.比较各组人体测量学参数、血糖、BP、血脂、胰岛素等指标的差别,及MS和主要组分的患病率. 结果 FDR组肥胖、腹型肥胖、IGR、高血压、高TG血症、低HDL-C血症、MS（MCEP-ATPⅢ标准）和MS（IDF标准）的患病率均高于NC组（P＜0.05或P＜0.01）,但低于T2DM组（P＜0.05或P＜0.01）. 结论 T2DM及相关的代谢异常如肥胖、高血压、脂代谢异常等存在明显的家族聚集性.T2DM家系中非糖尿病一级亲属已表现出不同程度的代谢异常.

The prevalence of metabolic syndrome and its related components in non-diabetic first-degree relatives in families with type 2 diabetes mellitus

Objective To understand the prevalence of metabolic syndrome and its components in non-diabetic first-degree relatives in families with T2DM.Methods 128 Enshi Tujia families with T2DM were enrolled and OGTT was performed.Anthropometry,blood pressure,lipid levels and OGTT were examined.Except second degree relatives and spouses who were diabetic relatives or who self-disease was diabetic,all the subjects were divided into three groups：T2DM group（n=332）,FDR group（n=298） and normal control group（n=102）.The clinical and metabolic characteristics and the prevalence of MS and its main components were compared among three groups.Results The prevalence of IGR,hypertension,hypertriglyceridemia,decreased blood HDL-C,MS （MCEP-ATPⅢ criterion） and （IDF criterion） were higher in FDR group than in normal control group,but lower than in T2DM group （P〈0.05 or P〈 0.01）.Conclusion There is significant familial aggregation of T2DM and related phenotypes such as obesity,hypertension and dyslipidaemia.There are metabolic disorder in different degree in the nondiabetic FDR.