| 苁蓉冲剂对环磷酰胺致白细胞减低症模型小鼠作用的观察 |
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| 引用本文： | 李得春,张永梅,胡同平,杨玉梅,乔姝,张利霞,杨丽,彭忠忠.苁蓉冲剂对环磷酰胺致白细胞减低症模型小鼠作用的观察[J].包头医学院学报,2014(5):9-11. |
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| 作者姓名： | 李得春 张永梅 胡同平 杨玉梅 乔姝 张利霞 杨丽 彭忠忠 |
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| 作者单位： | 1. 包头医学院第一附属医院,内蒙古 包头,014010
2. 包头医学院 |
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| 摘 要： | 目的：探讨苁蓉冲剂对环磷酰胺所致小鼠白细胞减少症的作用效果。方法：小鼠腹腔连续7 d注射环磷酰胺溶液（50 mg/kg）制成白细胞减少症模型,并用苁蓉冲剂进行灌胃,检测外周血象和T淋巴细胞亚群。结果：苁蓉冲剂可使模型小鼠外周血白细胞数、淋巴细胞数和血小板数升高,可使血红蛋白含量升高,可调节CD4^＋/CD8^＋细胞比例。结论：苁蓉冲剂可改善环磷酰胺所致白细胞减少症外周血象,调节免疫失衡。
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| 关 键 词： | 苁蓉冲剂 环磷酰胺 小鼠 白细胞减少症 |
The Effect of Congrong Granules on Leukopenia in Mice induced by Cyclophosphamide |
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| LI Dechun,ZHANG Yongmei,HU Tongping,YANG Yumei,QIAO Shu,ZHANG Lixia,YANG Li,PENG Zhongzhong.The Effect of Congrong Granules on Leukopenia in Mice induced by Cyclophosphamide[J].Journal of Baotou Medical College,2014(5):9-11. |
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| Authors: | LI Dechun ZHANG Yongmei HU Tongping YANG Yumei QIAO Shu ZHANG Lixia YANG Li PENG Zhongzhong |
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| Institution: | LI Dechun, ZHANG Yongmei, HU Tongping, YANG Yumei, QIAO Shu, ZHANG Lixia, YANG Li, PENG Zhongzhong ( The First Affiliated Hospital of Baotou Medical College, Baotou 014010, China ) |
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| Abstract: | Objective：To assess the effect of Congrong granules on cyclophosphamide - induced leukopenia in mice mod-els. Methods：The leukopenia mice models were established by consecutively injecting cyclophosphamide solution（50 mg/ kg） for 7 days and gavaged with Congrong granules,with the peripheral hemogram and subgroup of T lymphatic cells detested. Re-sults：Congrong granules could increased peripheral blood leukocyte count,lymphocytes count,blood platelet count and hemoglo-bin content,with the ratio of CD4^＋ / CD8^＋ cells modulated. Conclusion：Congrong granule can improve the peripheral hemogram of leukopenia induced by cyclophosphamide and regulate the immune imbalance. |
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| Keywords: | Congrong granule Cyclophosphamide Mice Leucopenia |
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