| tau 蛋白与阿尔茨海默病的研究进展 |
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| 引用本文： | 胡江平,耿瑞,李凯军.tau 蛋白与阿尔茨海默病的研究进展[J].中国康复理论与实践,2014,20(11):1031-1034. |
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| 作者姓名： | 胡江平 耿瑞 李凯军 |
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| 作者单位： | 牡丹江医学院，黑龙江牡丹江市157011 |
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| 基金项目： | 1.黑龙江省教育厅海外学人项目(No.1153h16)；2.牡丹江医学院科技项目(No.ZS201329；No.ZS201303)。 |
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| 摘 要： | 阿尔茨海默病(AD)的主要病理变化之一是神经元内出现以磷酸化tau 蛋白为主要成分的神经原纤维缠结。以往研究主要集中在老年斑及Aβ层面，近年来的研究表明，tau 蛋白与AD的发生发展有着密切联系，tau 蛋白异常磷酸化已成为目前的研究点。本文从蛋白激酶及磷酸酶角度对tau蛋白磷酸化与AD之间的关系进行综述。
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| 关 键 词： | 阿尔茨海默病 tau蛋白 磷酸化 神经原纤维缠结 综述 |
Advance in Relationship between Tau Protein and Alzheimer's Disease (review) |
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| HU Jiang-ping,GENG Rui,LI Kai-jun.Advance in Relationship between Tau Protein and Alzheimer's Disease (review)[J].Chinese Journal of Rehabilitation Theory and Practice,2014,20(11):1031-1034. |
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| Authors: | HU Jiang-ping GENG Rui LI Kai-jun |
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| Institution: | Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, China |
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| Abstract: | Alzheimer's disease is a common neurodegenerative disease. One of the main pathology is neurofibrillary tangles in neurons,in which principal component is the phosphorylation of tau protein. Previous studies focused on senile plaques and Aβ levels. Recent studies indicated that the development of tau protein closely associated with Alzheimer's disease, especially the abnormal phosphorylation. This paper reviewed the relationship between tau protein phosphorylation and Alzheimer's disease based on the perspective of protein kinases and phosphatases. |
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| Keywords: | Alzheime r's disease tau protein phosphorylation neurofibrillary tangles review |
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