| Mast cell- derived mediators protects PC12 cells against ischemia in vitro |
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| 引用本文： | Fan Yan-Yi Shen Yao Fu Qiu-Li Dai Hai-Bin Hu Wei-Wei Chen Zhong. Mast cell- derived mediators protects PC12 cells against ischemia in vitro[J]. 中国药理通讯, 2006, 23(4): 37-38 |
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| 作者姓名： | Fan Yan-Yi Shen Yao Fu Qiu-Li Dai Hai-Bin Hu Wei-Wei Chen Zhong |
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| 作者单位： | Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, China, 310058 |
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| 基金项目： | This project was supported by grants from the National Natural Science Foundation of China （30572176 and 30600757） and the Zhejiang Provincial Natural Science Foundation of China （R303779） |
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| 摘 要： | We have previously demonstrated that brain mast cells degranulated under ischemia in in vivo or in vitro experiments. However the true role of mast cells in the brain ischemia is still known. In the present study, we investigated the effect of the mediators from the mast cell on neuronal cell line PC12 in an in vitro ischemic model oxygen - glucose deprivation （OGD）. The supernatant of mast cells was collected ofter 1h OGD, and then incubated with the PC12 cells under lh OGD. Results showed that by the incorporation of the mast cell - derived supernatants, the survival of PC12 cells markedly increased after OGD exposure with or without 24h reperfusion. Histamine H1 receptor antagonist pyrilamine significantly reversed the effect of the mast cell - derived supernatants, which indicated the participation of histamine in this process. However histamine itself did not increased the survival of PC12 cells after OGD.
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| 关 键 词： | 肥大细胞衍生介质 PC12细胞 脑缺血 保护作用 |
Mast cell- derived mediators protects PC12 cells against ischemia in vitro |
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