Biological behavior of polypropylene meshes suitable for intra-abdominal implantation in animal model

The expected incisional hernia rate is between 11-20% after laparotomy. Using mesh repair the results of the hernioplasty have recently improved. However the complication of mesh implants--especially in intraperitoneal position--can be life threatening. Additionally the appropriate mesh is expensive. We tried to create a mesh, which can be used intraperitoneally and generates adhesion in the abdominal wall, but keeps the intraabdominal organs adhesion free. Our experiments were divided into four groups. In the first we used different materials to cover the intraperitoneal side of polypropylene mesh. In the second phase three different pore-sized meshes were compared. In the third part the biological behavior of three different material-reduced meshes were investigated. Based on our previous results in the last session we used only silicone membrane protected material-reduced polypropylene meshes to cover the abdominal defects. Our experiments have shown that intraperitoneal implant with silicone-covered Vypro (Ethicon)/Premilene (B. Braun Medical) mesh significantly decreases the formations of adhesion.