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| 细胞色素P450靶向抗肿瘤药物研发进展 | |
| 引用本文： | 郭建路,胡玥,刘闰平,江振洲,査晓明,张陆勇. 细胞色素P450靶向抗肿瘤药物研发进展[J]. 药学进展, 2010, 34(7): 298-305. DOI: 10.3969/j.issn.1001-5094.2010.07.002 |
| 作者姓名： | 郭建路 胡玥 刘闰平 江振洲 査晓明 张陆勇 |
| 作者单位： | 1. 中国药科大学江苏省新药筛选中心,江苏,南京,210009 2. 中国药科大学江苏省药效研究与评价服务中心,江苏,南京,210009 3. 中国药科大学药物质量与安全预警教育部重点实验室,江苏,南京,210009 4. 中国药科大学江苏省新药筛选中心,江苏,南京,210009;中国药科大学江苏省药效研究与评价服务中心,江苏,南京,210009 |
| 摘 要： | 细胞色素P450酶能催化各种内源性及外源性化合物的代谢,与多种肿瘤的发生发展有着密切关系,因此细胞色素P450酶靶向药物的研制已成为肿瘤治疗的新的研究方向之一,其中肿瘤特异性表达细胞色素P450酶成为研究热点。综述细胞色素P450酶靶向抗肿瘤药物研发进展,并介绍细胞色素P450 2W1及其靶向药物的研究近况。 |
| 关 键 词： | 细胞色素P450酶 靶向抗肿瘤药物 前药 代谢活化 细胞色素P4502W1 |
Recent Researches on Anti-tumor Drug Development by Targeting Cytochrome P450 |
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| GUO Jian-lu,HU Yue,LIU Run-ping,JIANG Zhen-zhou,ZHA Xiao-ming,ZHANG Lu-yong. Recent Researches on Anti-tumor Drug Development by Targeting Cytochrome P450[J]. Progress in Pharmaceutical Sciences, 2010, 34(7): 298-305. DOI: 10.3969/j.issn.1001-5094.2010.07.002 | |
| Authors: | GUO Jian-lu HU Yue LIU Run-ping JIANG Zhen-zhou ZHA Xiao-ming ZHANG Lu-yong |
| Affiliation: | 1.Jiangsu Center for Drug Screening,China Pharmaceutical University,Nanjing 210009,China;2.Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education,China Pharmaceutical University,Nanjing 210009,China;3.Jiangsu Center for Pharmacodynamics Research and Evaluation,China Pharmaceutical University,Nanjing 210009,China) |
| Abstract: | Cytochrome P450 enzymes （CYPs） have shown the catalytic activities in the metabolism of endogenous and exogenous compounds and were closely related to the genesis and development of tumors.It＇s a novel research to target CYPs for tumor chemotherapy,especially tumor-specific CYPs.The research and development of anti-tumor drugs targeting CYPs were reviewed and the preliminary studies on CYP2W1 and CYP2W1-targeting drugs were also introduced. |
| Keywords: | CYPs targeted anti-tumor drug prodrug metabolic activation CYP 2W1 |
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