先天性心脏病伴肺动脉高压患儿血浆神经肽Y、降钙素基因相关肽的研究

目的研究降钙素基因相关肽(CGRP)、神经肽Y(NPY)与先心病肺高压的关系,分析两者是否具有相关性.方法采用放射免疫法测定80例先天性心脏病(13例非肺高压,67例肺高压)血清NPY、CGRP的浓度,比较两组间不同采血部位及手术前后水平变化.结果血浆NPY及CGRP浓度非肺高压组与轻、中、重度肺高压组均存在显著性差异;手术前后轻、中度肺高压组存在显著性差异,而重度肺高压组差异不明显;NPY与CGRP存在负相关关系.结论NPY及CGRP在先天性心脏病肺动脉高压的发生机制中有重要的作用,NPY/CGRP比值可作为估测肺动脉压力和判断先心病预后的重要指标.

THE STUDY OF NEUROPEPTIDE Y AND CALCITONIN GENE RELATED PEPTIDE IN CONGENITAL HEART DISEASE WITH PULMONARY HYPERTENSION

Objective:The study elaborates the relationship between calcitonin gene related peptide(CGRP),neuropeptide Y(NPY) in congenital heart disease (CHD) with pulmonary hypertension(PH).We make a conelation analysis between the levels of serum CGRP and NPY.Methods:The levels of serum CGRP and NPY were tested by radioimmunoassay,amony the whole cases,67 patients have PH and 13 patients have not.Results:There were significant differences in serum levels of CGRP and NPY between the non-PH group and mild,moderate,severe PH groups.In mild and moderate PH groups,there were significant difference between the preoperational levels of NPY and CGRP and the postoperational levels of them.In severe PH group,there was not significant differences between the preoperational and postoperational levels of NPY and CGRP.There was modest negative corelation between the levels of NPY and CGRP.Conclusion:CGRP and NPY make important effects on the mechanism of CHD with PH.The elevation of NPY/CGRP has a great effect on the shaping and development of PH.