| p53、nm23-H1表达与大肠癌生物学行为的关系 |
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| 引用本文： | 张勤,孙凯. p53、nm23-H1表达与大肠癌生物学行为的关系[J]. 华中科技大学学报(医学版), 2001, 30(6): 569-570 |
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| 作者姓名： | 张勤 孙凯 |
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| 作者单位： | 襄樊市中心医院病理科,襄樊,441021 |
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| 摘 要： | 应用SABC免疫组织化学方法研究69例大肠癌中p53、nm23-H1的表达与其生物学行为的关系.结果发现大肠癌中p53、nm23-H1的阳性率分别为52.2%及68.1%,大肠癌中p53过表达与淋巴结转移有关(P＜0.0D,nm23-H1低表达与肿瘤浸润深度及淋巴结转移有关(P＜0.01),p53过表达与nm23-H1低表达在大肠癌淋巴结转移中可能起协同作用.结果提示同时检测p53、nm23-H1基因产物的表达状况可作为预测大肠癌淋巴结转移及预后的指标.
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| 关 键 词： | 大肠肿瘤 基因表达 淋巴结转移 免疫组织化学 |
| 修稿时间： | 2000-09-26 |
The Relationship between Expression of p53,nm23 H1 and the Behavior of Colorectal Cancer |
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| Zhang Qin,Sun Kai. The Relationship between Expression of p53,nm23 H1 and the Behavior of Colorectal Cancer[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2001, 30(6): 569-570 |
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| Authors: | Zhang Qin Sun Kai |
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| Affiliation: | Zhang Qin,Sun Kai Department of Pathology,Xiangfan Center Hospital,Xiangfan 441021 |
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| Abstract: | Using immunohistochemistry SABC method the expression of p53 and nm23 H1 genes in 69 cases of colorectal cancer and its correlation with lymph node metastasis and invasion were studied. The results showed that the positive rate of p53 and nm23 H1 protein in colorectal cancer was 52 2 % and 68 1 % respectively. Overexpression of p53 protein was positively related to lymph node metastasis ( P <0 01). Expression of nm23 H1 protein was negatively related to the invasive depth and lymph node metastasis ( P <0 01). Overexpression of p53 protein and low expression of nm23 H1 protein might have a synergic effect in lymph node metastasis of colorectal cancer. The results suggest that the sumultaneous delection of the expression of both p53 and nm23 H1 genes may serve as a marker of lymph node metastasis in colorectal cancer and evaluate the prognosis of the patients with colorectal cancer. |
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| Keywords: | colorectal neoplasms gene expression lymph node metastasis immunohistochemistry |
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