Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions |
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| Authors: | Suni Lee Shoko Yamamoto Yasumitsu Nishimura Hidenori Matsuzaki Kei Yoshitome Tamayo Hatayama Miho Ikeda Min YU Nagisa Sada Naoko Kumagai-Takei Takemi Otsuki |
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| Institution: | 1. Department of Hygiene, Kawasaki Medical School, 577 Mastushima, Kurashiki 701-0192, Japan;2. Department of Occupational and Environmental Health Science, School of Public Health, School of Public Health, Peking University Health Science Center, Beijing 100191, China;3. Department of Occupational Diseases, Zhejiang Academy of Medical Sciences, Hangzhou 310013, Zhejiang, China;4. Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushimanaka, Kita-Ku, Okayama 700-8530, Japan |
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| Abstract: | ObjectiveThe changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months ‘Off to On' and ‘On to Off' periods using negatively charged particle-dominant indoor air conditions (NCPDIAC).MethodsSeven volunteers participated in the study, which included ‘OFF to 3 months ON' periods (ON trials) for a total of 16 times, and ‘ON to 3 months OFF' (OFF trials) periods for a total of 13 times.ResultsWith the exception of one case, serum amyloid A (SAA) levels decreased significantly during the ON trials.ConclusionConsidering that SAA is an acute phase reactive protein such as C reactive protein (CRP), this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes, since an increase in high-sensitive CRP is associated with the subsequent detection of these events. |
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| Keywords: | Negatively charged particle Indoor air Serum amyloid A Biomarker Cardiovascular disease |
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