马来酸桂哌齐特治疗急性脑出血的临床研究

目的 探讨马来酸桂哌齐特对脑出血患者血肿吸收、周围水肿改善及神经功能恢复的影响。方法 将90 例患者随机分为治疗组(45例)和对照组(45例),分别于入组第1、7、21天利用CT测量血肿体积、水肿面积,并行 临床神经功能评分(chinese stroke seale,CSS)。治疗组给予5％葡萄糖500ml加马来酸桂哌齐特320 mg／d,连用14 d。结果 治疗组水肿面积、血肿体积和CSS均较对照组明显改善(P<0．01)。应用马来酸桂哌齐特治疗后第21 天水肿面积由(4．3±O．6)cm2变为(2．8±0．7)cm2,血肿体积由(19±5)ml变为(6±6)ml,CSS由(22±9)变为(9± 7)。对照组第21天水肿面积由(4．5±O．7)cm2变为(3．2±0．6)cm2,血肿体积由(20±5)ml变为(11±7)ml,CSS由 (23±8)变为(14±8)。两组比较,差异有显著意义(P

Study on Cinepazide Maleate in the Treatment of Acute Intracerebral Hemorrhage

Objective To explore the therapeutic effects of cinepazide maleate on absorptions of hematoma and edema of peripheral tissue and the neurological function in patients with intracerebral hemorrhage(ICH). Methods 90 patients with ICH were divided into 2 groups at random: treatment group and control group,45 patients in each group. Cinepazide maleate was given in the therapeutic group, while no cinepazide maleate was given in the control group. The volume of hematoma and area of edema were measured by CT. The neurological functions were assessed by Chinese Stroke Scale (CSS). Results The volume of hematoma and area of edema reduced markedly in the treatment group on 21th day after administration (P<0.01). CSS of the treatment group was lower than that of control group on 21th day after treatment (P<0.01). Conclusion Cinepazide maleate may be helpful for absorption of hematoma and the reduction of the edema of tissue around the hematoma and in improving the neurological function in patients with ICH.