Bone marrow-derived mesenchymal stem cells are capable of mediating hepatitis B virus infection in injured tissues |
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| Authors: | Rong Q Zhang L Su E Li J Li J Liu Z Huang Z Ma W Cao K Huang J |
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| Affiliation: | Department of Cardiology;;Department of Infectious Disease;;Department of Hematology, First Affiliated Hospital of Nanjing Medical University;;and Department of Cardiology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China |
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| Abstract: | Summary. We have previously showed that endothelial progenitor cells (EPCs) through uptake of hepatitis B virus (HBV) may play a critical role in mediating extrahepatic HBV diseases. However, it remains to be elucidated whether mesenchymal stem cells (MSCs) are capable of mediating HBV trans-infection into extrahepatic tissues. Methods and Results: In this study, we showed that HBV antigens, HBV DNA and the viral particles were detected in MSCs after 3 days virus challenge. Neither HBV covalently closed circular DNA nor pregenomic RNA were detected in MSCs. Intravenously transplantation of HBV-exposed MSCs into myocardial infarction mouse model resulted in incorporation of HBV into injured heart and other damaged tissues. Conclusion: These results indicate that MSCs could serve as an additional extrahepatic virus reservoir, which may play a role at least in part in mediating HBV trans-infection into the injured tissues through the process of MSCs recruitment. |
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| Keywords: | extrahepatic disorder hepatitis B virus mesenchymal stem cell transplantation |
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