Synthesis of anionic derivatives of myo-inositol and other polyols and investigation of their antiviral activity |
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Authors: | O A Tuchnaya O V Gorlachuk V A Livshits I I Kashiricheva N S Shastina A M Yurkevich V I Shvets |
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Institution: | (1) M. V. Lomonosov Moscow State Academy of Fine Chemical Technology, Moscow, Russia;(2) State Scientific Center for Antibiotics, Moscow, Russia |
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Abstract: | The search for new, effective antiviral agents currently includes assessment of polyanionic compounds of various structures;
these are highly active inhibitors of viral penetration into cells. The present report describes the preparation of phosphate
and sulfate derivatives based on 2,3,4,5-tetra-O-benzyl-D,L-iditol, 1,12-dodecanediol, and a dimeric analog of inositol-containing phospholipids. The dimeric derivative, which contains
two myo-inositol cyclitol rings linked by a single hydrophobic fragment, was synthesized at high yield using the H-phosphonate method.
The antiviral activity of the series of compounds synthesized here was assessed against a panel of viruses. All were inactive
against rhinoviruses; the disulfate of tetra-O-benzyl-D,L-iditol inhibited Coxsackie virus and had the greatest cytotoxicity; the disulfate of 1,2-dodecanediol was inactive against
all viruses, while the diphosphate of 2,3,4,5-tetra-O-benzyl-D,L-iditol and the monosulfate of 1,2-dodecanediol were active against herpes simplex viruses types 1 and 2.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 1, pp. 6–12, January, 2008. |
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