阻塞性睡眠呼吸暂停综合征患者生活质量与情绪等相关性研究

目的　探讨阻塞性睡眠呼吸暂停综合征 (OSAS)患者健康相关生活质量 (HRQoL)与情绪状态、疾病严重程度、白天过度嗜睡 (EDS)等之间的关系。方法　对确诊的 10 8例OSAS患者采用Calgary生活质量指数 (SAQLI)评价HRQoL、Epworth嗜睡量表 (ESS)评价EDS、Zung抑郁自评量表(SDS)评价情绪。用简单直线相关和多元逐步回归的方法分析SAQLI评分与SDS评分、ESS评分、PSG参数等之间的关系。结果　SAQLI四部分以及总分均与PSG参数无关 ,与SDS和ESS评分明显相关 ;多元逐步回归发现SDS和ESS是SAQLI的独立预测因素 ,两个变量共可解释SAQLI总分变化的 2 8 3% (R2 =0 2 83,P <0 0 1)。结论　OSAS患者的生活质量与抑郁情绪和过度嗜睡密切相关 ;抑郁情绪是影响OSAS患者生活质量的最重要因素。

Relationship between health-related quality of life and mood in patients with obstructive sleep apnea

Objective To assess the association of health-related quality of life (HRQoL) with severity of obstructive sleep apnea syndrome (OSAS),excessive daytime sleepiness (EDS),and mood in patients with OSAS.Methods 108 patients with OSAS were assessed for HRQoL using the Calgary quality of life index (SAQLI),for EDS using the Epworth sleepiness scale (ESS),and for mood using the Zung self-rated depression scale (SDS).The association between each domain and the total score on SAQLI and the polysommographic parameters,person factors,ESS score,SDS score were examined by Person linear correlation and stepwise multiple regression analysis.Results There was no relationship between SAQLI and the severity of OSAS.Four domains and the total score on SAQLI were significantly correlated with the SDS and ESS score.Stepwise multiple regression analysis selected two variables,the SDS score and ESS score,as independent factors for predicting the total score of SAQLI which accounted for the 28.3% of the total variance in the total score on SAQLI (R 2 =0.283,P<0.001).Conclusions The HRQoL of patients with OSAS was strongly correlated with the depression scale and ESS score.Mood is the most important factor to affect the HRQoL of patients with OSAS.