Quantitative analysis of the immunogenic activity of SV40 virus and of tumor cells induced by this virus

A study of specific antitumor immunity created in Syrian hamsters by oncogenic virus SV40 and by tumor cells induced by the same virus showed that the level of specific resistance depends on the immunizing dose of virus and cells. Investigation of the resistance-inducing activity of a wild strain of SV40 virus showed that the minimal dose inducing resistance in hamsters was ten times higher than for the tsA-30 mutant of the virus. The minimal resistance-inducing dose of irradiated cells of a tumor induced by the same strain of SV40 virus was 9·10⁵ cells; a tenfold increase in the dose led to a significant increase in the level of specific antitumor immunity.Laboratory of Immunology of Tumors, Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR L. M. Shabad.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 8, pp. 223–225, August, 1978.