子宫内膜癌hMSH2及PTEN蛋白的异常表达

目的]探讨错配修复基因hMSH2及抑癌基因PTEN异常表达在子宫内膜癌发生中的意义。方法]采用免疫组织化学SP法检测62例子宫内膜癌和16例子宫内膜增生过长组织hMSH2及PTEN蛋白的表达情况,率的差异比较采用卡方检验。结果]子宫内膜癌与子宫内膜增生过长组hMSH2蛋白的阳性表达率为64.52%与18.75%,两组差异显著(P<0.05);PTEN蛋白表达缺失率为64.52%与50.00%,差异不显著(P>0.05)。PTEN蛋白表达缺失与子宫内膜癌组织分化程度及患者年龄不相关(P>0.05);PTEN蛋白的表达缺失率在hMSH2蛋白阳性表达组为70.00%,高于阴性表达组的54.55%,但差异不显著(P>0.05)。结论]抑癌基因PTEN的错配可能是子宫内膜癌发生的原因。

Abnormal expressions of hMSH2 and PTEN protein in endometrial carcinoma

Objective] To study the significance of abnormal expressions of DNA mismatch repair gene hMSH2 protein and tumor suppressor genes PTEN protein in endometrial carcinoma.Method] Immunohistochemical method was used to detect the expressions of hMSH2 and PTEN protein in 62 cases of endometrial carcinoma(EC),16 cases of endometrial hyperplasia(EH).Results] The positive expression rates of hMSH2 protein in EC and EH groups were 64.25% and 18.75%(P<0.05);the negative expression rates of PTEN protein in EC and EH groups were 64.25% and 50.00%(P>0.05);the deletion expression of PTEN protein was not significantly related to the differentiation of endometrial carcinoma and the patient age(P>0.05);the negative expression rate of PTEN protein being 70.00% in the hMSH2 positive expression group was higher than that being 54.55% in the hMSH2 negative expression group,but the difference was not significantly(P>0.05).Conclusion] The mismatch of tumor suppressor gene PTEN may play a role in the endometrial carcinogenesis.