冬凌草中的一个新生物碱

目的:研究冬凌草(Rabdosia rubescens (Hemls.) Hara)地上部分的化学成分。方法:利用大孔吸附树脂色谱进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果:从冬凌草地上部分分离得到7个化合物,分别为:冬凌草碱(1),黄嘌呤(2),芹菜素-6,8-二-C-β-D-葡萄糖苷(3),7-羟基-4(1H)-喹啉酮(4),1,5-二-(3,4-二羟基苯基)-乙烯醚(5),3-(3,4-二羟基苯基)-2-异丙氧基-丙酸(6),邻苯二甲酸双-(2-乙基己基)酯(7)。结论:化合物1为新化合物,其余化合物均为首次从该属植物中分离得到。

A New Alkaloid from the Aerial Part of Rabdosia rubescens

AIM: To study the chemical constituents of the aerial part of Rabdosia rubescens (Hemls.) Hara. METHODS: Fresh sample of the aerial part of Rabdosia rubescens was extracted with 70% Me2CO, discolored by activated charcoal. The concentrated material was partitioned with ether, ethyl acetate, and n-butanol. The fraction of n-BuOH extract was chromatographed over Diaion HP-20 and Toyopearl HW-40 column chromatography. The compounds were identified on the basis of their physiochemical and spectral data. RESULTS: Seven compounds, including a new alkaloid which was named donglingine (1) , were isolated from the aerial part of Rabdosia rubescens. The structure of compound 1 was elucidated as 3R-4-(N-(3, 7-dihydroxy-2-oxo-1, 2, 3, 4-tetrahydro-quinolin-6-yl)-acetamido)-butanamide. The other six known compounds were identified as xanthine (2), apigenin-6, 8-di-C-β-D-glucopyranoside (3), 7-hydroxy-4(1H)-quinolinone (4), trans-1, 5-di-(3, 4-dihydroxyphenyl)-divinyl ether (5), 3-(3, 4-dihydroxyphenyl)-2-isopropoxy-propionic acid (6), bis-(2-ethylhexyl)-phthalate (7). CONCLUSIONS: Compound 1 is a new compound and the other six known compounds were isolated from this genus for the first time.