Experimental and clinical studies on inhibitory effect of Ganoderma lucidum on platelet aggregation |
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Authors: | Tao Jun Feng Ke-yan |
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Institution: | (1) Department of Internal Medicine, Tongji Hospital, Tongji Medical University, Wuhan |
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Abstract: | Summary In this study we observed the inhibitory effect of Chinese herbal medicine Ganoderma lucidum (GL) on platelet aggregation
in 15 healthy volunteers and 33 patients with atherosclerotic diseases. The results showed that the first and the second phase
of aggregation of platelets of the healthy volunteers were obviously inhibited (P<0.0l) when watery soluble extract of GL of different concentrations was added to the platelets in vitro, i. e., the reaction
speed of platelet aggregation was slowed down. The inhibitory effect was related to dosage. Platelet aggregation induced by
ADP in final concentration of 2 μmol/L and 3 μmol/L was obviously inhibited, after the patients had taken GL 1 g 3 times a
day for 2 weeks, the maximum platelet aggregation inhibition rates were then 31.49 % (P<0.0l) and 17.7 % (P<0.0l) respectively. Length and weights (wet and dry) of the extracorporeal thrombi were reduced from 30.05±4.38 mm, 103.9±9.33mg
and 44.89±4.79 mg to 20.4±2.33 mm (P<0.05), 85.27±8.77 mg (P<0.0l) and 35.1=±4.5 mg (P<0.0l) respectively after oral administration of GL. The results of our experiments suggested that the Chinese herbal medicine
GL may be an effective inhibitory agent of platelet aggregation. However, its mechanism and active principles remain to be
further investigated. |
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Keywords: | Ganoderma lucidum platelet aggregation inhibitory agent |
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