首页 | 本学科首页   官方微博 | 高级检索  
     


Laser induced thermal injury of rabbit cornea and treatment with anti-inflammatory agents
Authors:John A. Wolfe  Bruce E. Stuck  Steven T. Schuschereba  Leslie P. Fox
Affiliation:(1) Division of Ocular Hazards, Letterman Army Institute of Research, Presidio of San Francisco, 94129, CA, USA;(2) Ophthalmology Service, Letterman Army Medical Center, Presidio of San Francisco, 94129, CA, USA;(3) Ophthalmology Department, Phoenix Indian Medical Center, 4212 N. 16th Street, 85016 Phoenix, AZ, USA
Abstract:A moderately severe thermal injury of the central cornea of 48 Dutch-belted rabbit eyes was produced with a carbon (CO2) laser. The lesions were photographed with a slit lamp (SL) camera immediately following the injury and at 1, 2, 4, 7, 14, 21, 30 and 60 days after the exposure. Lesion size, opaqueness, and depth were graded clinically by SL biomicroscopy at the same intervals. No significant differences were found (p les 0.05) between groups of eyes treated with flurbiprofen (0.03%), prednisolone acetate (1%), and vehicle control four-times-a-day for three weeks following injury. Additionally, eyes were studied histopathologically at 3 and 60 days following injury by light and transmission electron microscopy, and clinically at 30 and 60 days by endothelial specular microscopy. Important clinical and histopathological findings included coagulative necrosis of the corneal epithelium, epithelial sloughing, fusion of stromal collagen, stromal edema and inflammatory cell infiltration, stromal scar formation, corneal thinning, endothelial hyperplasia and metaplasia, fibrinous anterior chamber reaction with hypopyon, and retrocorneal fibrous membrane formation.
Keywords:corneal thermal injury  carbon dioxide (CO2) laser  flurbiprofen, prednisolone  epithelium, stroma  corneal thinning  endothelial hyperplasia  metaplasia  hypopyon  retrocorneal fibrous membrane
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号