beta-Carboline binding to deoxycholate solubilized benzodiazepine receptors from calf cerebral cortex |
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Authors: | R Sherman-Gold Y Dudai |
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Affiliation: | 1. Department of Physiology, St. George''s Hospital Medical School, London SW17, U.K.;2. Department of Pharmacology, St. Thomas'' Hospital Medical School, London SW1, U.K. |
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Abstract: | The beta-carbolines harmane and norharmane competitively inhibit [3H]flunitrazepam ([3H]FNZ) binding to deoxycholate-solubilized benzodiazepine receptors from calf cerebral cortex, with Ki in the micromolar range [3H]Propyl-beta-carboline-3-carboxylate ([3H]PrCC) binds to the soluble receptors with an affinity similar to its binding to particulate receptors (0.41 nM vs 0.48 nM, respectively). The component that binds [3H]PrCC displays a sedimentation profile on sucrose gradient centrifugation similar to that of [3H]FNZ binding component (sedimentation coefficient about 11S). |
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Keywords: | To whom correspondence should be addressed. |
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