| 胆木叶化学成分研究 |
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| 引用本文： | 谢达温,李永辉,赵丽,丁岗,原少伟,徐甲,朱华荣,萧伟.胆木叶化学成分研究[J].中国中药杂志,2011,36(8):1037-1039. |
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| 作者姓名： | 谢达温 李永辉 赵丽 丁岗 原少伟 徐甲 朱华荣 萧伟 |
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| 作者单位： | 1. 江苏中康药物科技有限公司,江苏,南京,210017;中药制药过程新技术国家重点实验室,江苏,连云港,222001;江苏省企业院士工作站,江苏,连云港,222001
2. 江苏中康药物科技有限公司,江苏,南京,210017;江苏康缘药业股份有限公司,江苏,连云港,222001;中药制药过程新技术国家重点实验室,江苏,连云港,222001;江苏省企业院士工作站,江苏,连云港,222001 |
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| 基金项目： | 国家重大新药创制项目(2009ZX09103-379);江苏省科技支撑-社会发展项目(BE2009618) |
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| 摘 要： | 目的:研究胆木叶的化学成分.方法:采用柱色谱法和半制备高效液相色谱法进行分离和纯化,通过波谱分析鉴定其化学结构.结果:分离得到5个已知化合物,分别为异长春花苷内酰胺(strictosamicle,1),10-羟基异长春花苷内酰胺(10-hydroxy strictosamide,2),山奈酚-3-O-芸香糖苷(kaempferol-3-O-rutinoside,3),芦丁(rutin,4),短小蛇根草苷(pumiloside,5).结论:化合物2,3,4是首次从胆木叶中分离得到.
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| 关 键 词： | 胆木叶 NMR 化学成分 |
| 收稿时间： | 2011/3/16 0:00:00 |
Study on chemical constituents from leaves of Naudea officinalis |
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| XIE Dawen,LI Yonghui,ZHAO Li,DING Gang,YUAN Shaowei,XU Ji,ZHU Huarong and XIAO Wei.Study on chemical constituents from leaves of Naudea officinalis[J].China Journal of Chinese Materia Medica,2011,36(8):1037-1039. |
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| Authors: | XIE Dawen LI Yonghui ZHAO Li DING Gang YUAN Shaowei XU Ji ZHU Huarong and XIAO Wei |
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| Institution: | Jiangsu Zeukov Pharmaceutical S. & T. Inc., Nanjing 210017, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jiangsu Zeukov Pharmaceutical S. & T. Inc., Nanjing 210017, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jiangsu Zeukov Pharmaceutical S. & T. Inc., Nanjing 210017, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jiangsu Zeukov Pharmaceutical S. & T. Inc., Nanjing 210017, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jiangsu Zeukov Pharmaceutical S. & T. Inc., Nanjing 210017, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jiangsu Zeukov Pharmaceutical S. & T. Inc., Nanjing 210017, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jiangsu Zeukov Pharmaceutical S. & T. Inc., Nanjing 210017, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China;Jiangsu Zeukov Pharmaceutical S. & T. Inc., Nanjing 210017, China;Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222000, China;State Key Laboratory of Pharmaceutical New-tech for Chinese Medicine, Lianyungang 222001, China;Enterprises Academician Workstations in Jiangsu Province, Lianyungang 222001, China |
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| Abstract: | Objective : To study the chemical constituents of the leaves of Naudea officinalis. Method : The chemical constituents were separated by column chromatography and semi-preparative HPLC techniques, and their structures were determined by spectral analysis. Result : Five compounds were isolated and identified as strictosamide( 1 ), 10-hydroxy strictosamide( 2 ), kaempferol-3-O-rutinoside( 3 ), rutin( 4 ), pumiloside( 5 ). Conclusion : Among these compounds, 2, 3, 4 are isolated from the leaves of Naudea officinalis for the first time. |
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| Keywords: | leaves of Naudea officinalis NMR chemical constituents |
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