婴儿肝炎综合征的病因分析及其肝组织的光镜和电镜的观察研究

本文报道了16例临床和病理诊断一致的婴儿肝炎综合征，其中14例用ELISA法检测多种病毒，并采用聚合酶链反应（PCR）法检测巨细胞病毒（CMV）－DNA，还用电镜观察了肝组织的超微结构变化。研究结果发现本组的主要病因是CMV感染，共有9例，占56．3％，其余为甲型肝炎病毒感染2例，EB病毒感染和肝外胆道闭锁各1例，还有3例原因不明。14例电镜下主要见肝细胞胞浆基质疏松，线粒体、内质网、高尔基氏器和糖原减少，溶酶体和脂滴增多。尽管本组病例的病因有多种，但在光镜和电镜下所见的病理变化基本一致。

Studies of the Etiology of Hepatitis Syndrome in Infancy and Observations of the Pathomorphology of the Liver by Microscope and Electron Microscope

Sixteen cases of hepatitis syndrome in fancy were diagnosed by clinic and pathology in this paper. Fourteen cases amollg them were measured a series of virus antigens and antibodies by ELISA,and cytomegalovirus (CMV) -DNA by polymerase chain reaction (PCR ), and observed ultrastructures of liver tissue by electron microscope. The results showed that CMV infection is the main cause for hepatitis syndrome of infancy. Nine of 16 cases were infectedby CMV (56. 3% ). Other causes included 2 cases of hepatitis a virus infection. one of EB virus infection and one of biliary atresia,however 3 cases of pathogenesis were not clear. Under the electron microscpoe,the liver cells in 14 cases showed that the cytoplasm loosened,the mitochondria, endoplasmic reticulum, Golgiapparatuse, and glycogen decreased, and the lysosome and lipid droplet increased. Although there were different causes in this group of patients, the pathomorphology of liver under the microscpoe and electron microscope observation was similar.