自由基清除剂及高压氧治疗血管性认知功能障碍的研究

目的观察自由基清除剂(FRS)联合高压氧(HBO)治疗血管性认知功能障碍(VCI)的临床疗效。方法 153例血管性认知功能障碍患者,随机分为自由基清除剂组、高压氧+自由基清除剂组及对照组。比较治疗前后各组简易智力状态检查量表(MMSE)、韦氏成人记忆量表(WMS)及日常生活能力评定量表(ADL)的评分。结果治疗后,自由基清除剂组、高压氧+自由基清除剂组的MMSE、WMS及ADL评分均较治疗前明显改善,且均优于对照组,高压氧+自由基清除剂治疗组又优于单纯自由基清除剂组。结论自由基清除剂联合高压氧治疗可明显改善VCI患者的MMSE、WMS及ADL评分,疗效提高,值得临床进一步推广应用。

The Research of Free Radical Scavenger and Hyperbaric Oxygen Treatment for Vascular Cognitive Dysfunction

Objective To observe the clinical efficacy of free radical scavenger and hyperbaric oxygen treatment of vascular cognitive impairment(VCI).Methods 153 vascular cognitive disorders patients were randomly divided into 3 groups: free radical scavenger group,hyperbaric oxygen and free radical scavenging group,and control group.Compare the changes of mini-mental state examination(MMSE),Wechsler Adult Memory Scale(WMS) and assessment of activities of daily living scale(ADL) score before and after treatment.Results After treatment,the MMSE,WMS,and ADL scores in free radical scavenger group,hyperbaric oxygen + free radical scavenger group are significantly improved than before,and are superior to the control group;hyperbaric oxygen + radical scavenging agent treatment group is better than simple free radical scavenger group.Conclusion free radical scavenger and hyperbaric oxygen therapy can significantly improve the MMSE,WMS,and ADL scores of VCI patients,improve the clinical efficacy,and worthy of further promotion and application.