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FENCLOFENAC AND DICLOFENAC IN THE TREATMENT OF RHEUMATOID ARTHRITIS |
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| Authors: | BEDI, S. S. EBERL, R. MILLION, R. SILAS, A. M. |
| Affiliation: | 1North Tees General Hospital Stockton-on-Tees 2 Krankenhaus Lainz, Wien (Vienna), Austria 3Hope Hospital Salford 4Oldchurch Hospital Romford, Essex |
| Abstract: | A six month single-blind, randomized parallel group study comparingthe effects of fenclofenac and diclofenac in 63 patients withrheumatoid arthritis is described. Both treatments producedimprovements in clinical measurements, with a significant between-treatmenteffect in favour of fenclofenac for overall pain, night painand duration of morning stiffness. Both treatments produceda decrease in IgM and the fenclofenac group produced decreasesin plasma viscosity and ESR, the latter showing a significantbetween-treatment effect in favour of fenclofenac. No clinicallysignificant changes in routine haematology and biochemistrywere noted. Unwanted effects leading to withdrawal of therapywere reported by five patients in the fenclofenac group andthree patients in the diclofenac group. Two patients in thefenclofenac group and one in the diclofenac group were withdrawnfor reasons unrelated to therapy. In the diclofenac group twoand four patients were withdrawn for clinical deteriorationand inadequate effect respectively. KEY WORDS: Rheumatoid arthritis, Fenclofenac, Diclofenac |
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