青少年甲亢131I治疗的临床初探

目的：探讨青少年甲亢１３１Ｉ治疗的临床疗效、副作用及治疗后病人满意度情况等问题。方法：对８９例１４～２５岁（甲状腺Ⅱ度肿大以上）的青少年甲亢采用１３１Ｉ治疗后随访３年以上的资料进行分析，并利用信访或面谈等形式了解患者对该治疗方法的满意度情况。结果：８９例患者中，一次治愈６１例（占６８．５％），好转１４例（占１５．７％），甲低（永久性）１１例（占１２．４％），无效３例（占３．４％）；从已随访到的情况看，所有患者治疗后无发生甲状腺结节、甲状腺癌变、其它癌或白血病病例，２６例已婚生育者后代中无致畸现象发生；１３１Ｉ治疗后，对该治疗方法８１例（９１％）认为满意，５例（５．６％）认为一般，不满意者３例（３．４％）。结论：　１３１Ｉ是治疗青少年甲亢有效、经济、相对安全的方法，患者对该治疗方法满意度高，对甲状腺肿大明显（Ⅱ度以上）、病程长的青少年甲亢患者，１３１Ｉ治疗是值得推荐的方法。

Clinical study of adolescent hyperthyroidism after 131I therapy

Objective:To probe into the clinical curative effect, side effect and gratification degree of adolescent hyperthyroidism after 131I therapy. Methods: To analyse the material of 89 cases (age range from 14-25 ) treated with 131I for Grave's disease over 3 years follow-up and the patients gratification degree to the treatment was known with mail or interview. Results: 61 cases (68.5%) were once cured among the 89 patients, improvement in 14 cases (15.7%), hypothyroidism in 11 cases(12.4%), ineffective in 3 cases (3.4%). There were no thyroid nodules, thyroid cancer ,other malignancies or leukemia in all cases after treatment, neither were teratogenesis in progeny of 26 legitimate. After 131I therapy, 91% of patients were satisfied, 5.6% felt it common, only 3.4% dissatisfied. Conclusion: 131I is found to be an effective, economic and safe treatment of Graves' disease in adolescents ( especially to the obviously goitrous patients) , the treated patients have high gratification and it should be the preferred mode of therapy.