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| 阿尔茨海默病脑灰质体积异常的MRI研究 | |
| 引用本文： | 李淑宇,蒲放,蒋田仔,刘爱珍,谢晟,王荫华. 阿尔茨海默病脑灰质体积异常的MRI研究[J]. 中国医学影像技术, 2006, 22(8): 1162-1164 |
| 作者姓名： | 李淑宇 蒲放 蒋田仔 刘爱珍 谢晟 王荫华 |
| 作者单位： | 1. 北京航空航天大学生物工程系,北京,100083 2. 中科院自动化所模式识别国家重点实验室,北京,100080 3. 首都医科大学附属北京同仁医院,北京,100730 4. 北京大学第一医院放射科,北京,100034 5. 北京大学第一医院神经内科,北京,100034 |
| 基金项目： | 本研究得到国家自然科学基金项目(60121302)，北京市自然科学基金(3052009,3063024)资助。 |
| 摘 要： | 目的研究阿尔茨海默病(AD)患者MRI图像脑灰质萎缩的模式。方法对19例AD患者和20例正常老年对照者行MRI扫描,通过优化的基于体素的形态学(optimizedvoxelbasedmophometry,OVBM)分析方法,分析AD患者全脑和局部脑灰质的体积异常。结果AD患者全脑灰质体积相对于正常对照者明显降低(P=0.0048),双侧海马、双侧丘脑、双侧颞上回和左侧颞中回体积明显减少(多重校正后,相当于P<0.05)。结论AD患者的全脑灰质体积明显降低,局部区域明显萎缩。 |
| 关 键 词： | 灰质 磁共振成像 阿尔茨海默病 基于体素的形态学分析 |
| 文章编号： | 1003-3289（2006）08-1162-03 |
| 收稿时间： | 2006-05-30 |
| 修稿时间： | 2006-07-30 |
MRI study on abnormal gray matter volume in Alzheimer''s disease |
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| LI Shu-yu,PU Fang,JIANG Tian-zi,LIU Ai-zhen,XIE Sheng and WANG Yin-hua. MRI study on abnormal gray matter volume in Alzheimer''s disease[J]. Chinese Journal of Medical Imaging Technology, 2006, 22(8): 1162-1164 | |
| Authors: | LI Shu-yu PU Fang JIANG Tian-zi LIU Ai-zhen XIE Sheng WANG Yin-hua |
| Affiliation: | 1. Department of Bioengineering, Bei Hang University, Beij ing 100083, China ; 2. National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China; 3. Beij ing Tongren Hospital, Capital University of Medical Sciences, Beij ing 100730, China; 4. Department of Radiology, 5. Department of Neuropsychology, Peking University First Hospital, Beijing 100034, China |
| Abstract: | Objective To find the pattern of gray matter atrophy of Alzheimer's disease (AD). Methods Conventional MRI were performed in 19 AD patients and 20 age-and gender-matched healthy controls. Then the volumes of global and local gray matter were analyzed by optimized voxel-based morphometry. Results Compared to the normal aging, the global gray matter volumes of AD decreased severely (P=0.0048). The local atrophy regions focused on the bilateral hippocampus, bilateral superior temporal gyrus, and bilateral thalamus (P<0.05 corrected for multiple comparisons). Conclusion The global and local gray matter volumes of AD have markedly reduced. |
| Keywords: | Gray matter Magnetic resonance imaging Alzheimer's disease Voxel-based morphometry |
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