抗VEGF治疗在儿童眼底病中的应用

血管内皮生长因子(VEGF)是胚胎时期眼球发育过程中血管形成的关键介质,也是在多种眼科疾病中引起视网膜新生血管形成和血管通透性改变的重要因子。随着抗VEGF治疗在成人的应用逐渐成熟,越来越多的研究关注于抗VEGF治疗在儿童眼底病的应用,包括早产儿视网膜病变(ROP)、Coats病、家族性渗出性玻璃体视网膜病变(FEVR)、色素失禁症相关视网膜病变、镰状细胞视网膜病、视网膜母细胞瘤及各种病因引起的脉络膜新生血管等。本文将对抗VEGF在这些眼底病中的应用现状作一综述。

Anti-VEGF therapy in pediatric retinal and choroidal disease

Vascular endothelial growth factor(VEGF)is a key factor of the angiogenesis during embryonic period, and it is also an important mediator of the pathological neovascularization and vascular permeability in various ophthalmic diseases. With the increasing use of anti-VEGF therapy in adults, more and more clinical studies are focused on the application of anti VEGF therapy in pediatric retinal and choroidal diseases, including retinopathy of prematurity, Coats disease, familial exudative vitreoretinopathy, incontinence pigmented related retinopathy, sickle cell retinopathy, retinoblastoma and choroidal neovascularization caused by various causes. In this article, the application of anti VEGF therapy in these pediatric retinal and choroidal diseases was reviewed.