| Comparison of early changes in ocular surface markers and tear inflammatory mediators after femtosecond lenticule extraction and FS-LASIK |
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| 作者姓名： | Chi Zhang Hui Ding Hong He He Jin Liang-Ping Liu Xiao-Wei Yang Jun Yang Xing-Wu Zhong |
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| 作者单位： | 1National Center for Children''s Health, MOE Key Laboratory of Major Diseases in Children, Department of Ophthalmology, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China |
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| 基金项目： | Supported by the National Natural Science Foundation of China(No.81870681);Key Program of the Department of Science and Technology of Hainan Province(No.ZDYF2020151);Huaxia Translational Medicine Fund For Young Scholars(No.2017-D-001);Medical Science and Technology Research Foundation of Guangdong Province(No.A2020406)。 |
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| 摘 要： | AIM:To compare the short-term impacts of femtosecond lenticule extraction(FLEx)and femtosecond laser-assisted laser in situ keratomileusis(FS-LASIK)on ocular surface measures and tear inflammatory mediators.METHODS:This prospective comparative nonrandomized clinical study comprised 75 eyes(75 patients).Totally 20 male and 15 female patients(age 21.62±3.25 y)with 35 eyes underwent FLEx,and 26 male and 14 female patients(age 20.18±3.59 y)with 40 eyes underwent FS-LASIK.Central corneal sensitivity,noninvasive tear breakup time,corneal fluorescein staining,Schirmer I test,tear meniscus height,and ocular surface disease index were evaluated in all patients.Tear concentrations of nerve growth factor(NGF),interleukin-1α(IL-1α),transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),and matrix metalloproteinase-9(MMP-9)were assessed by multiplex antibody microarray.All measurements were performed preoperatively,and 1 d,1 wk,and 1 mo postoperatively.RESULTS:Patients who underwent FLEx exhibited a more moderate reduction in central corneal sensation and less corneal fluorescein staining than those in the FS-LASIK group 1 wk after the procedure(P<0.01).NGF was significantly higher 1 d and 1 wk after surgery in the FS-LASIK group than in the FLEx group(P<0.01).By contrast,compared to those in the FLEx group,higher postoperative values and slower recovery of tear TGF-β1,IL-1α,and TNF-αconcentrations were observed in the FS-LASIK group(P<0.01).Tear concentrations of NGF,TGF-β1,TNF-α,and IL-1αwere correlated with ocular surface changes after FLEx or FS-LASIK surgery.CONCLUSION:There is less early ocular surface disruption and a reduced inflammatory response after FLEx than after FS-LASIK.NGF,TGF-β1,TNF-α,and IL-1αmay contribute to the process of ocular surface recovery.
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| 关 键 词： | femtosecond lenticule extraction femtosecond laser-assisted laser in situ keratomileusis tear inflammatory mediators ocular surface |
| 收稿时间： | 2019/9/23 0:00:00 |
| 修稿时间： | 2020/9/1 0:00:00 |
Comparison of early changes in ocular surface markers and tear inflammatory mediators after femtosecond lenticule extraction and FS-LASIK |
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| Chi Zhang,Hui Ding,Hong He,He Jin,Liang-Ping Liu,Xiao-Wei Yang,Jun Yang,Xing-Wu Zhong.Comparison of early changes in ocular surface markers and tear inflammatory mediators after femtosecond lenticule extraction and FS-LASIK[J].International Journal of Ophthalmology(English edition),2021,14(2):283-291. |
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| Authors: | Chi Zhang Hui Ding Hong He He Jin Liang-Ping Liu Xiao-Wei Yang Jun Yang and Xing-Wu Zhong |
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| Institution: | Huaxia Eye Hospital of Foshan, Huaxia Eye Hospital Group, Foshan 528000, Guangdong Province, China; Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China,Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou 570311, Hainan Province, China,Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou 570311, Hainan Province, China,Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China,Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China,Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China,Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China and Zhongshan Ophthalmic Center and State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510000, Guangdong Province, China; Hainan Eye Hospital and Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Haikou 570311, Hainan Province, China |
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| Abstract: | |
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| Keywords: | recurrent epiblepharon modified skin re-draping epicanthoplasty Chinese children |
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