干性年龄相关性黄斑变性免疫学机制的研究进展

干性年龄相关性黄斑变性(ARMD)是一种发病机制尚不完全明确的退行性眼底病变,可造成中心视力不可逆的损失,以黄斑部色素紊乱、玻璃膜疣生成及地图样萎缩为主要眼底表现。免疫与炎性反应在本病的发展过程中起到关键作用,免疫分子中的补体系统、模式识别受体、炎症小体及多种细胞因子等均与干性ARMD的发生密切相关。现将这些免疫分子与干性ARMD的最新研究进展做一综述。

Advances in immunological mechanism of dry age-related macular degeneration

Dry age-related macular degeneration(ARMD)is a degenerative fundus disease whose pathogenesis is not yet fully clear. Dry ARMD with macular pigmentation disorder, drusen and geographic atrophy as main manifestations can lead to irreversible loss of central vision. It''s reported that immune and inflammatory reactions play a key role in the development of dry ARMD, in which complement system, pattern recognition receptors, inflammasomes, and various cytokines in immune molecules are closely related to the occurrence of dry ARMD. In this paper, the latest researches on these immune molecules and dry ARMD will be reviewed.