| 人脑胶质瘤中MMP-9、CD133蛋白的表达及临床意义 |
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| 引用本文： | 马庆防,杨梅,陈剑,种衍军.人脑胶质瘤中MMP-9、CD133蛋白的表达及临床意义[J].现代保健,2012(3):8-10. |
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| 作者姓名： | 马庆防 杨梅 陈剑 种衍军 |
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| 作者单位： | [1]济南大学 [2]山东省医学科学院附属济宁市第一人民医院,272000 [3]山东省医学科学院医学与生命科学学院 ,272000 [4]山东省医学科学院附属济宁市第一人民医院西院区,272000 |
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| 摘 要： | 目的 探讨人脑胶质瘤中基质金属蛋白酶-9（MMP-9）、肿瘤干细胞标志物CD133蛋白的表达及临床意义.方法 采用免疫组织化学方法检测66例不同级别胶质瘤组织标本及15例正常脑组织标本中MMP-9、CD133蛋白表达.结果 人脑胶质瘤标本中MMP-9、CD133蛋白表达明显升高;CD133及MMP-9蛋白总的阳性细胞表达率随着胶质瘤病理级别的增加而增高（P〈0.01）;人脑胶质瘤中CD133蛋白的阳性细胞表达率和MMP-9蛋白阳性细胞表达率成正相关（P〈0.01）.结论 人脑胶质瘤中MMP-9、CD133蛋白的表达与脑胶质瘤的恶性程度密切相关;可能在脑胶质瘤的侵袭性生长、复发和转移过程中起协同作用.
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| 关 键 词： | 胶质瘤 基质金属蛋白酶-9 CD133蛋白 肿瘤干细胞 |
Expression and clinical significance of MMP-9 and CD133 protein in human gliomas |
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| Institution: | MA Qing -fang , YANG Mei, CHEN Jian, et al.( Jining First People＇s Hospital Affiliated to Shandong Provincial Academy of Medical Science,Jining 272000,China) |
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| Abstract: | Objective To study the expression and clinical significance of MMP -9 and CD133 protein in human gliomas. Methods Sixty - six cases of gliomas and fifteen cases of normal brain tissues were tested by immunohistochemistry for MMP - 9 and CD133 protein. Results The expression of CD133 and MMP -9 were significantly higher in human gliomas than that in normal brain tissues. It was shown that the MMP -9 and CD133 protein expression were closely correlated with the grade of gliomas. There was a positive reciprocity between the positive rates of CD133 and MMP - 9 protein in human gliomas（P 〈0. 01 ）. Conclusion There is a close relationship between the higher levels expression of MMP -9, CD133 protein and the progression of gliomas, which may play important roles together in aggressive growth,relapse and metastasis of gliomas. |
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| Keywords: | Glioma Matrix metalloproteinase - 9 CD133 protein Tumor stem cell |
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