不同剂型米索前列醇用于无痛人工流产术的临床观察

目的比较米索前列醇粉剂和片剂用于无痛人工流产的临床效果。方法选择需行无痛人工流产术的未产妇女200例,按随机原则分为A组和B组各100例,A组手术前1h阴道放置米索前列醇粉剂400μg,B组术前1h阴道放置米索前列醇片剂400μg,比较两组患者术中宫颈扩张程度、手术时间、术中出血量和不良反应。结果 A组在术中宫颈扩张程度、手术时间和术中出血量方面均明显优于B组,差异均有统计学意义（P〈0.05）,而两组不良反应比较差异无统计学意义（P〉0.05）。结论在无痛人工流产术中,米索前列醇粉剂短时间内能更好地扩张宫颈,缩短手术时间,减少术中出血。

Clinical observation of different dosage form of misoprostol in painless artificial abortion

Objective To compare the clinical effects of misoprostol powder and tablets in painless artificial abortion. Methods 200 nullipara who require to do painless artificial abortion were randomly divided into group A and group B, 100 cases in each. One hour be- fore surgery, Group A was gave 400 trg misoprostol powder by vaginal and Group B was gave 400 ~g misoprostol tablets by vaginal. The intr- aoperative cervical dilatation, operative time, blood loss and adverse reactions were observed and compared. Results Group A is better than group B in intraoperative cervical dilatation, operative time and the amount of bleeding, and there were significant differences statistically （ P 〈 O. 05 ）. However, there is no significant differences statistically in adverse reactions （ P 〉 0. 05 ）. Conclusion Misoprostol powder can be better to expand the cervix, shorten the operation time, reduce the amount of bleeding within a short time in painless artificial abortion.