手术与少腹逐瘀汤治疗子宫腺肌病临床疗效对比研究

目的 通过对比手术与中药少腹逐瘀汤对子宫腺肌病患者痛经缓解程度和治疗前后实验室指标的变化水平,评价两种治疗方式的临床疗效.方法 60例子宫腺肌病患者随机分为手术组和中药组,每组30例,随访时间为3个月,评估两组患者治疗前后痛经程度及血液学指标的变化,评估两种疗法的疗效和优势.结果 （1）手术组临床有效率（100%）显著高于中药组（80%）（P〈0.05）;（2）两组患者治疗后NRS/PPI评分、CA125水平均较治疗前明显下降,手术组下降程度大于中药组（P〈0.05）;（3）两组TXB2水平、T/K比值治疗后均较前降低（P〈0.05）,治疗后中药组明显低于手术组（P〈0.05）.结论 相对于中药治疗,手术治疗治愈率明显增高,且能显著改善子宫腺肌病患者疼痛程度;而中药在改善微循环和活血化瘀方面疗效明显优于手术.两种疗法均能调节激素失衡状态.因此,临床上建议手术与中药少腹逐瘀汤联合的综合疗法将对子宫腺肌病取得更好的临床疗效.

The contrast study of curative effect of surgeon and Shao Fu Zhu Yu soup to treat adenomyosis

Objective To evaluate the clinic effects of two different treatment methods by comparing dysmenorrhea degree and laboratory index changes of the patients underwent operation with that of the patients treated with traditional Chinese drug Shao Fu Zhu YU soup. Methods 60 patients finally diagnosed for adenomyosis were divided randomly into two groups, surgery group and traditional Chinese drug group, with 30 patients in each one. Follow - up time was three months. By observation and comparative analysis of the dysmenorrhea degree score and CA125 change in the two groups, the ultimate motive was to observe the curative effect and advantage of the two different treatments. Results （ 1 ） The total effective rate in the two groups respectively was 100% and 80%, thus the result had obvious statistic difference （P 〈 0.05 ）. （2）The NRS/PPI scores and CA125 level after treatments were lower than that before curatios, thus the result had obvious statistic difference （P 〈 0. 05 ） , especially in the operation group. （3）The TXB2 level were lower after treatments in two groups, especially in the traditional Chinese drug group, the result between the two groups had obvious statistic difference （P 〈 0.05 ）. Conclusion Compared with Shao Hu Fu Zhu Yu soup, surgeon increases manifestly recovery rate, releases the pain degree of adenomyosis. However, the traditional Chinese drug is superior to the operation in improving minicirculation and activating blood circulation to dissipate blood stasis. By surgeon and traditional Chinese drug treatment, the hormone disequilibrium state will be regulated. Thus, the complex therapy of operation and traditional Chinese drug can increase healing rate and alleviate algomenorrhea symptom.