术前应用倍他乐克的老年非心脏手术患者术后心脏不良事件调查

目的探讨老年非心脏手术患者术前48 h开始预防性服用倍他乐克是否能够降低围术期心脏不良事件的发生率.方法76例65岁以上拟行择期非心脏手术、具有ACC/AHA＂非心脏手术围术期心血管风险评估指南＂中至少一项中危因素同时不存在高危因素的患者,随机分为倍他乐克组和对照组,每组38例.倍他乐克组于术前48 h开始至术晨早晚各口服倍他乐克25～50 mg,对照组术前不服用任何β-受体阻滞剂.围术期监测（1）记录术中发生血流动力学紊乱的病例数和处理血流动力学紊乱所用药物的总用量及气道压;（2）入选患者在术前1周内服用倍他乐克前任1 d、手术当天至术后1～3 d进行Holter监测记录围术期心脏不良事件的发生情况;（3）术前1周内服用倍他乐克前1 d、手术结束后2 h、术后1～3 d测定肌钙蛋白I.结果对照组发生高血流动力学紊乱的患者例数和硝酸甘油用量多于倍他乐克组,差异有显著统计学意义（P〈0.01）.SBP〈90 mmHg、HR〈50次/min的患者例数和麻黄素、阿托品用量两组间差异无统计学意义（P〉0.05）;倍他乐克组没有明显的气道压升高.两组术前Holter监测发现的心肌缺血例数无显著性差异（P〉0.05）;术中、术后发现的心脏不良事件病例数组间差异有统计学意义（P〈0.05）,术中对照组8例、倍他乐克组1例发生心肌缺血;术后对照组有17例患者发生心肌缺血,其中2例并存室速、4例并存房颤,3例伴肌钙蛋白I阳性的心肌缺血,倍他乐克组3例发生心肌缺血;两组患者术后均未发生心肌梗死及死亡.结论术前48 h口服倍他乐克可以降低老年非心脏手术患者围术期心脏不良事件的发生率,且不增加心血管及呼吸系统副反应的发生.

Relationships between Preoperative Use of Betaloc and Perioperative Adverse Cardiac Events in Elderly Patients Underwent Noncardiac Surgery

Objective To research whether prophylactic Betaloc two days before surgery can reduce the incidence of perioperative cardiac adverse events in elderly patients underwent noncardiac surgery.Methods 76 patients over 65 years underwent elective noncardiac surgery were enrolled in the study.And all patients were conformed to the standards of classification of risk factors for clinical history in at least one intermediate risk factor,content of Guidelines on Preoperative Cardiovascular Evaluation for Noncardiac ...