|
|||||
|
|
| Survivin在胆管癌细胞核中的表达及其与预后的关系 | |
| 引用本文： | 左克强,艾开兴,郭兴军,宋自芳,陈立波,郑启昌. Survivin在胆管癌细胞核中的表达及其与预后的关系[J]. 华中科技大学学报(医学版), 2007, 36(4): 478-481 |
| 作者姓名： | 左克强 艾开兴 郭兴军 宋自芳 陈立波 郑启昌 |
| 作者单位： | 1. 同济大学附属同济医院普外科,上海,200065 2. 上海交通大学附属第六人民医院肝胆外科,上海,200233 3. 华中科技大学同济医学院附属协和医院肝胆外科,武汉,430022 |
| 摘 要： | 目的探讨胆管癌细胞核中Survivin的表达及其在提示预后方面所起的作用。方法48例手术切除的胆管癌标本作为研究对象，应用免疫组织化学技术（SP法）检测Survivin在48例胆管癌中的表达情况。Survivin的表达分别描述为阴性、弱阳性和强阳性。结果Survivin在胞质和细胞核表达例数分别为26例和22例。细胞质中强阳性表达为12例，而细胞核强阳性表达的则有8例。细胞核强阳性表达的患者中位存活期为10个月，明显低于弱阳性表达的患者（19个月，P=0.035）。Cox比例风险模型的多因素分析证实存在2个独立的预后因素：Survivin细胞核表达（P=0.018）和远处转移（P=0.027）。结论胆管癌细胞核中Survivin的表达可能提示较差的预后。 |
| 关 键 词： | 胆管癌 预后 |
| 修稿时间： | 2005-09-15 |
Expression of Survivin in Nucleus of Cholangiocarcinoma Cells and Its Relation with Prognosis |
|
| Zuo Keqiang , Ai Kaixing , Guo Xingjun et al. Expression of Survivin in Nucleus of Cholangiocarcinoma Cells and Its Relation with Prognosis[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 2007, 36(4): 478-481 | |
| Authors: | Zuo Keqiang Ai Kaixing Guo Xingjun et al |
| Affiliation: | 1.Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022 ;2.Department of Hepatobiliary Surgery, the Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233 |
| Abstract: | Objective To study the prognostic role of Survivin expression in nucleus of cholangiocarcinoma cells.MethodsIn 48 specimens surgically resected from patients with cholangiocarcinoma,immunohistochemistry(SP method) was used to detect the expression of Survivin in nucleus of cholangiocarcinoma cells.Results Survivin was expressed in cytoplasm(26 cases) and nucleus(22 cases).Strong expression of Survivin in cytoplasm and nucleus were seen in 12 and 8 cases respectively.The mean survival time of the patients positive for strong expression of Survivin in nucleus was 10 months,significantly shorter than those with weak nuclear survivin expression(19 months,P=0.035).Multivariate analysis using the Cox-proportional hazards model identified 2 independent prognostic predictors: nuclear survivin expression(P=0.018) and presence of distant metastasis(P=0.027) Conclusion The expression of Survivin in nucleus of cholangiocarcinoma cells may predict a poor prognosis. |
| Keywords: | Survivin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |