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Synthesis and antimalarial activity of dihydroperoxides and tetraoxanes conjugated with bis(benzyl)acetone derivatives |
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| Authors: | Franco Lucas Lopardi de Almeida Mauro Vieira E Silva Luiz Francisco Rocha Vieira Pedro Paulo Ribeiro Pohlit Adrian Martin Valle Marcelo Siqueira |
| Affiliation: | Departamento de Química, Universidade Federal de Juiz de Fora, Campus Universitário s/n, Martelos, Juiz de Fora, MG, Brazil. |
| Abstract: | Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC50 ≤ 5.0 μm ) against blood forms of the human malaria parasite Plasmodium falciparum. |
| Keywords: | antiplasmodial antiprotozoal malaria Plasmodium falciparum |
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