急性早幼粒细胞型白血病止血凝血检测及其临床意义

目的：探讨争民性早幼粒细胞型白血病的止血凝血变化及其对临床意义的影响。方法：应用放射免疫法、单抗酶联免疫法和发色底物法，对21例初入院的急性早幼粒细胞型白血病（APL）患者于化疗前和获得完全缓解后，进行血浆血栓烷（TXB2）、血管性假血友病因子抗原（VWF：Ag)、抗凝血酶原-Ⅲ（AT-Ⅲ）以及纤维蛋白原（Fg)、凝血酶原时间（PT）等检测，并与正常对照观察。结果：化疗前21例患者血浆TXB2、WVF：Ag、AT-Ⅲ、PT、Fg水平与正常对照比较有明显不同（分别P＜0.05,P＜0.01,P＜0.01,P＜0.01,P＜0.01)，经治疗后获得完全缓解的13例患者血浆TXB2、VWF：Ag、AT-Ⅲ、PT、Fg水平与化疗前对照亦有明显不同（分别P＜0.05,P＜0.01,P＜0.01,P＜0.01,P＜0.01)。结论：APL患者的止血凝血障碍由多种因素形成，而且患者止血凝血障碍的 病理变化是普遍存在的。

Clinical observations of haemostasis and coagulaton disorder in acute premyeloblastic luekemia

Objective: To investigate clinical observations of the haemostasis and coagulation of acute promyeloblastic leukemia. Methods: In 21 cases of acute premyeloblastic leukemia (APL)who were admitted to hospital for the first time, the plasma thromboxane B2 (TXB 2), von willebrand factor antigen (VWF:Ag), antithrombin III (AT III), fibrogen (Fg), prothrombin (PT) and other haemostatic coagulation parameters were measured using radioimmunoassay (RIA), monoclonic antibody enzyme linked immunosorbent assay and chromogenic peptide substrate assay methed before chemotherapy and after complete remission (CR). Results: It showed the TXB 2, VWF:Ag, AT III, PT, Fg levels were significantly different in APL patients before chemotherapy from the normal control (P<0 05, P<0 01, P<0 01, P<0 01, P<0 01) and compared with the 13 patients in the same group after CR (P<0 05, P<0 01, P<0 01, P<0 01, P<0 01 respectively) other haemostatic and coagulation paramethers also demonstrated some changes. Conclusion: The haemostatic and coagulation disturbance may universally exist and multifarious elements contribute to the imbanlance.