| Human plasma DNP level after severe brain injury |
| |
| 引用本文： | 高宜录,辛惠宁,冯毅,樊冀伟. Human plasma DNP level after severe brain injury[J]. 中华创伤杂志(英文版), 2006, 9(4): 223-227 |
| |
| 作者姓名： | 高宜录 辛惠宁 冯毅 樊冀伟 |
| |
| 作者单位： | Department of Nuclear Medicine Affiliated Hospital of Nantong University，Department of Nuclear Medicine Affiliated Hospital of Nantong University，Department of Nuclear Medicine Affiliated Hospital of Nantong University，Department of Neurosurgery Affiliated Hospital of Nantong University Nantong 226001，China，Nantong 226001，China，Nantong 226001，China，Nantong 226001，China |
| |
| 摘 要： | Objective: To determine the relationship between DNP level after human severe brain injury and hyponatremia as well as isorrhea. Methods: The peripheral venous plasma as control was collected from 8 volunteers. The peripheral venous plasma from 14 severe brain injury patients were collected in the 1,3,7 days after injury. Radioimmunoassay was used to detect the DNP concentration. Meanwhile, daily plasma and urine electrolytes, osmotic pressure as well as 24 h liquid intake and output volume were detected. Results: The normal adult human plasma DNP level was 62. 46 pg/ml±27. 56 pg/ml. In the experimental group, the plasma DNP levels were higher from day 1 to day 3 in 8 of the 14 patients than those in the control group (P1 =0.05, P3 =0.03). Negative fluid balance occurred in 8 patients and hyponatremia in 7 patients. The increase of plasma DNP level was significantly correlated with the development of a negative fluid balance (r = -0.69, P<0.01) and hyponatremia (X2=4.38, P<0.05). Conclusions: The increase of plasma DNP level is accompanied by the enhancement of natriuretic and diuretic responses in severe brain-injured patients, which is associated with the development of a negative fluid balance and hyponatremia after brain injury.
|
| 关 键 词： | 等离子体 急性脑损伤 病理机制 治疗 |
| 收稿时间： | 2005-08-11 |
Human plasma DNP level after severe brain injury |
| |
| GAO Yi-lu,XIN Hui-ning,FENG Yi,FAN Ji-wei. Human plasma DNP level after severe brain injury[J]. Chinese journal of traumatology, 2006, 9(4): 223-227 |
| |
| Authors: | GAO Yi-lu XIN Hui-ning FENG Yi FAN Ji-wei |
| |
| Affiliation: | 1. Department of Nuclear Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China
2. Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong 226001, China |
| |
| Abstract: | OBJECTIVE: To determine the relationship between DNP level after human severe brain injury and hyponatremia as well as isorrhea. METHODS: The peripheral venous plasma as control was collected from 8 volunteers. The peripheral venous plasma from 14 severe brain injury patients were collected in the 1, 3, 7 days after injury. Radioimmunoassay was used to detect the DNP concentration. Meanwhile, daily plasma and urine electrolytes, osmotic pressure as well as 24 h liquid intake and output volume were detected. RESULTS: The normal adult human plasma DNP level was 62.46 pg/ml+/-27.56 pg/ml. In the experimental group, the plasma DNP levels were higher from day 1 to day 3 in 8 of the 14 patients than those in the control group (P(1)=0.05, P(3)=0.03). Negative fluid balance occurred in 8 patients and hyponatremia in 7 patients. The increase of plasma DNP level was significantly correlated with the development of a negative fluid balance (r =-0.69, P<0.01) and hyponatremia (chi(2) =4.38, P<0.05). CONCLUSIONS: The increase of plasma DNP level is accompanied by the enhancement of natriuretic and diuretic responses in severe brain-injured patients, which is associated with the development of a negative fluid balance and hyponatremia after brain injury. |
| |
| Keywords: | Brain injury Hyponatremia Water-electrolyte balance |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
