多囊卵巢综合征胰岛素抵抗相关治疗进展

 胰岛素抵抗（IR）是多囊卵巢综合征（PCOS）重要发病机制之一。临床上应用二甲双胍或噻唑烷二酮类药物可改善PCOS患者IR，纠正其代谢紊乱和高雄激素血症，故有助于恢复正常月经，增加排卵率及妊娠率，且孕期应用二甲双胍可能减少流产、妊娠高血压病、妊娠糖尿病等并发症。

Progress in treatment of insulin resistance in polycystic ovary syndrome

Insulin resistance plays a key role in the pathogenesis of polycystic ovary syndrome. Therefore thiazolidinediones and metformin, which have been used in clinical therapy to treat patients with polycystic ovary syndrome, can ameliorate insulin resistance,resulting in the improvement of some metabolic abnormalities, hyperandrogenic symptoms, menses, ovulation and pregnancy rates. Metformin therapy throughout pregnancy may reduce in pregnancy complications, such as miscarriage rate, gestational hypertension and gestational diabetes.