Ozone-induced accelerated lung clearance of 99mTc-DTPA aerosol in conscious sheep |
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Authors: | W J Hornof E Schelegle M Kammerman R A Gunther P E Fisher C E Cross |
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Institution: | Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616. |
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Abstract: | This study was initiated to determine the rate and characteristics of 99mTc-DTPA clearance from the lungs of unanesthetized sheep exposed to varying concentrations of O3 for 4 h in a whole-body exposure chamber. Four sheep exposed to 1 ppm O3 had a monoexponential T50 of 274 +/- 81 min (SD), not significantly different from sham exposures (316 +/- 150); 5 sheep exposed to 2 ppm had a T50 of 234 +/- 101 min, not significantly different from sham exposures (364 +/- 131 min). Five additional unanesthetized sheep exposed to 2 ppm for 4 h via a nasotracheal tube had a T50 of 192 +/- 55 min, significantly different from sham exposures (300 +/- 96 min). The results show that the effect of oxidant pollutants on the permeability of alveolobronchiolar epithelium may be assessed in conscious sheep. |
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