灰质异位的功能磁共振成像研究(附3例报告)

目的:对灰质异位进行运动功能的功能磁共振成像研究,探讨异位灰质的神经生理功能及功能磁共振成像在神经外科中的作用。方法:采用功能磁共振成像技术对3例拟行手术治疗的灰质异位且伴癫痫症状的患者进行对指运动任务下的脑区反应观察。结果:2例顶叶灰质异位患者在对侧手指运动时异位灰质内出现明显的反应信号,否定外科手术治疗计划。1例额叶的灰质异位患者异位灰质内未出现反应。结论:异位的灰质可以具有运动中枢功能,对于靠近主要功能中枢的灰质异位患者在手术计划的拟定时要考虑异位灰质是否具有功能。功能磁共振成像可以用于评价灰质异位的神经生理,有助于治疗方法的选择。

Functional MRI Study in Patients with Heterotopic Gray Matter(with Report of Three cases)

Objective:To study the the neurophysiology of heterotopic gray matter using functional MRI associated with motor task and the guidance function of fMRI in neurosurgery. Methods:fMRI was used to localize the areas of motor activation in 3 patients with heterotopic gray matter who all suffered from epilepsy and prepared to be treated by surgery.Results:There was obvious activation in the heterotopic gray matter nearby lobus parietalis in 2 patients when contralateral fingers were tapping.On the other hand there was no activation in lobus frontalis heterotopic gray matter of the third patient when contralateral finger was tapping.Conclusion:Heterotopic gray matter can response part of the functional activity of the brain.The function of heterotopic gray matter must be considered before surgery especially when the heterotopic gray matter was nearby the important functional cortex.fMRI is an appropriate tool that can be used to study the neurophysiology of heterotopic gray matter,and can help the treatment planning.