| 大肠癌中MMP-2的作用 |
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| 引用本文： | 熊吉东,赵瑞波.大肠癌中MMP-2的作用[J].哈尔滨医科大学学报,2003,37(1):59-60. |
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| 作者姓名： | 熊吉东 赵瑞波 |
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| 作者单位： | 1. 哈尔滨铁路中心医院普外科
2. 哈尔滨医科大学,病理学教研室,黑龙江,哈尔滨,150086 |
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| 摘 要： | 目的 探讨基质金属蛋白酶(MMP—2)在大肠癌中的作用。方法 采用免疫组织化学方法检测35例大肠癌和10例正常大肠组织中MMP—2的表达.结果 检测出MMP—2在大肠癌和正常组织中的阳性率分别为45．7％(16／35)和20、0％(2／10)，大肠癌组织的MMP—2阳性率明显高于正常组织(P＜0．05)。MMP—2的表达与大肠癌的Dukes分期、浸润程度、淋巴结转移呈正相关(P＜0、01)。结论:MMP—2在大肠癌的发生、发展和转移过程中起着很重要的作用。
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| 关 键 词： | 大肠癌 基质金属蛋白酶 MMP－2 免疫组织化学 Dukes分期 浸润程度 淋巴结转移 关系 |
| 文章编号： | 1000-1905(2003)01-0059-02 |
| 修稿时间： | 2002年12月30 |
Function of matrix metalloproteinase-2 in colorectal carcinoma |
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| XIONG Ji dong,ZHAO Rui bo.Function of matrix metalloproteinase-2 in colorectal carcinoma[J].Journal of Harbin Medical University,2003,37(1):59-60. |
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| Authors: | XIONG Ji dong ZHAO Rui bo |
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| Abstract: | Objective To probe into the function of matrix metalloproteinase 2(MMP 2) in the colorectal carcinoma.Methods The expression of MMP 2 in 35 cases with colorectal carcinoma and 10 cases of normal colorectal tissues was detected with S P immunohistochemical method. Results The positive rate of MMP 2 in colorectal carcinoma and normal colorectal tissues was 45.7%(16/35)and 20.0%(2/10)respectively. And the positive rate of MMP 2 in the colorectal carcinoma was obviously higher than in the normal colorectal tissues( P <0.05). The expression of MMP 2 was positive correlated with Dukesstaging, the degree of invasion and lymph node matastasis( P <0.01). Conclusion MMP 2 plays a key role in the origin, development and metastasis of colorectal carcinoma. |
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| Keywords: | matrix metalloproteinase 2 immunohistochemistry colorectal carcinoma |
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