| 脓毒症生物标志物的最新进展 |
| |
| 引用本文： | 赵景昕,缪朝玉,徐添颖. 脓毒症生物标志物的最新进展[J]. 药学实践杂志, 2021, 39(6): 491-498 |
| |
| 作者姓名： | 赵景昕 缪朝玉 徐添颖 |
| |
| 作者单位： | 海军军医大学药理学教研室, 上海 200433;海军军医大学药理学教研室, 上海 200433;海军军医大学麻醉药理学教研室, 上海 200433 |
| |
| 基金项目： | 国家自然科学基金重点项目(81730098)；海军军医大学高等级成果培植计划(2018-CGPZ-A03) |
| |
| 摘 要： | 脓毒症可以导致危及生命的器官功能障碍，是危重患者死亡的主要原因之一。脓毒症的早期诊断与正确治疗是降低病死率的关键，但目前尚无诊断的金标准。理想的脓毒症生物标志物应该具有早期诊断和预测不良预后的能力，且具有较好的敏感性和特异性。脓毒症的候选生物标志物众多，本文重点综述了急性期蛋白、可溶性受体、非编码RNA和其他近期关注度较高的候选标志物的最新进展。
|
| 关 键 词： | 脓毒症 生物标志物 诊断 预后 |
| 收稿时间： | 2021-05-12 |
| 修稿时间： | 2021-10-07 |
Recent advances in biomarkers of sepsis |
| |
| ZHAO Jingxin,MIAO Chaoyu,XU Tianying. Recent advances in biomarkers of sepsis[J]. The Journal of Pharmaceutical Practice, 2021, 39(6): 491-498 |
| |
| Authors: | ZHAO Jingxin MIAO Chaoyu XU Tianying |
| |
| Affiliation: | Department of Pharmacology, Naval Medical University, Shanghai 200433, China; Department of Pharmacology, Naval Medical University, Shanghai 200433, China;Department of Anesthetic Pharmacology, Naval Medical University, Shanghai 200433, China |
| |
| Abstract: | Sepsis can cause life-threatening organ dysfunction and is one of the leading causes of death in critically ill patients. Early diagnosis and correct treatment of sepsis are the key to reducing the fatality, however, there is no golden standard for diagnosis at present. The ideal sepsis biomarker can be used for early diagnosis and predicting poor prognosis with good sensitivity and specificity. There are many candidate biomarkers for sepsis. This article reviews the latest developments on acute phase proteins, soluble receptors, non-coding RNAs and other candidate biomarkers of sepsis that attracted more recent attention. |
| |
| Keywords: | sepsis biomarker diagnosis prognosis |
|
| 点击此处可从《药学实践杂志》浏览原始摘要信息 |
|
点击此处可从《药学实践杂志》下载全文 |
|
