|
|||||
|
|
| CDX2和MUC2在胃癌组织中的表达 | |
| 引用本文： | 胡南,赵瑞波,谢志平,兴桂华.CDX2和MUC2在胃癌组织中的表达[J].齐齐哈尔医学院学报,2009,30(2):132-134. |
| 作者姓名： | 胡南 赵瑞波 谢志平 兴桂华 |
| 作者单位： | 1. 齐齐哈尔医学院,161006 2. 哈尔滨医科大学基础医学院病理学与病理生理学硕士研究生,161006 3. 齐齐哈尔医学院病理教研室,161006 |
| 摘 要： | 目的探讨CDX2与MUC2在胃癌组织中的表达及其意义。方法采用免疫组织化学方法检测胃癌组织及正常胃粘膜中CDX2与MUC2的表达。结果在正常胃粘膜组织中CDX2和MUC2均无阳性表达。CDX2与MUC2在胃癌组织中阳性表达率分别为51.92%和55.77%。CDX2在肠型胃癌中阳性表达率为65.62%（21/32）,在弥漫型胃癌中阳性表达率为30.0%（6/20）,两型胃癌中CDX2阳性表达率有显著性差异（P〈0.05）。MUC2在肠型胃癌中阳性表达率为68.75%（22/32）,在弥漫型胃癌中阳性表达率为35.0%（7/20）,两型胃癌中MUC2阳性表达率有显著性差异（P〈0.05）。CDX2和MUC2的表达与胃癌分化程度有关（P〈0.05）,与有无淋巴结转移无关（P〉0.05）。CDX2的表达和肿瘤浸润的深度有关（P〈0.01）,MUC2表达与肿瘤浸润的深度也有关（P〈0.05）。结论CDX2与MUC2在胃癌尤其是肠型胃癌中高表达,提示CDX2和MUC2与肠型胃癌的发生更密切。 |
| 关 键 词： | CDX2 MUC2 肠型胃癌 弥漫型胃癌 免疫组织化学 |
Expression of CDX2 and MUC2 protein in gastric cancer |
|
| HU Nan,et al..Expression of CDX2 and MUC2 protein in gastric cancer[J].Journal of Qiqihar Medical College,2009,30(2):132-134. | |
| Authors: | HU Nan |
| Institution: | Pathology Department;Qiqihar Medical University;Qiqihar;Heilongjiang 161006 China |
| Abstract: | Objective To investigate the expression of CDX2 and MUC2 in the gastric carcinoma(GC)and its significance. Methods The expression CDX2 and MUC2 were detected by immunohistochemistry with GC,normal gastric mucosa as control subjects.Results Neither CDX2 nor MUC2 was expressed in the normal gastric mucosa.The positive expression rate of CDX2 was 65.62% in intestinal type GC and30.0% in diffuse type GC,shown significant difference between the two groups(P<0.05).The positive expression of MUC2 was 68.75% in int... |
| Keywords: | CDX2 MUC2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |