| DETECTION AND ANALYSIS OF MULTIDRUG RESISTANCE IN 100 CASES OF ACUTE LEUKEMIA |
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| 引用本文： | 杨纯正,栾凤君,邵晓峰,李滨,卞寿庚. DETECTION AND ANALYSIS OF MULTIDRUG RESISTANCE IN 100 CASES OF ACUTE LEUKEMIA[J]. 中国癌症研究, 1995, 7(3): 193-196. DOI: 10.1007/BF03023473 |
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| 作者姓名： | 杨纯正 栾凤君 邵晓峰 李滨 卞寿庚 |
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| 作者单位： | Institute of Hematology Chinese Academy of Medical Sciences and Peking Union Medical College，Tianjin 300020 |
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| 摘 要： | ＤＥＴＥＣＴＩＯＮＡＮＤＡＮＡＬＹＳＩＳＯＦＭＵＬＴＩＤＲＵＧＲＥＳＩＳＴＡＮＣＥＩＮ１００ＣＡＳＥＳＯＦＡＣＵＴＥＬＥＵＫＥＭＩＡＹａｎｇＣｈｕｎｚｈｅｎｇ；杨纯正；ＬｕａｎＦｅｎｇｕｎ；栾凤君；ＳｈａｏＸｉａｏｆｅｎｇ；邵晓峰；ＬｉＢｉｎ；李滨；...
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Detection and analysis of multidrug resistance in 100 cases of acute leukemia |
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| Chunzheng Yang,Fengjun Luan,Xiaofeng Shao,Bin Li,Shougeng Bian. Detection and analysis of multidrug resistance in 100 cases of acute leukemia[J]. Chinese Journal of Cancer Research, 1995, 7(3): 193-196. DOI: 10.1007/BF03023473 |
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| Authors: | Chunzheng Yang Fengjun Luan Xiaofeng Shao Bin Li Shougeng Bian |
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| Affiliation: | 1. Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, 300020, Tianjin
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| Abstract: | Bone marrow specimens from 100 cases of acute leukemia (AL) diagnosed by MIC were detected with fluorescence microscopy for their mdr-1 expression using monoclonal antibody JSB-1 against P-glycoprotein (Pgp). The results showed that almost all subtypes of AL had Pgp expression and M5 of ANLL had a significantly higher expression rate in the newly diagnosed group. The MDR expression highly correlated with the clinical drug resistance and prognosis. The positive rate of Pgp (20.8%±14.9%) and MDR expression (78.9%) in refractory group were significantly higher than those in the newly diagnosed group (7.5%±9.8% and 18.2%), respectively. Cases with MDR+ expression had poor response to chemotherapy and bad prognosis. Supported by the grant from National Natural Science Foundation of China, No. 39170851 and the found for 8th Five-year Plan Key Projects, No. 85-914-03-10. |
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| Keywords: | Leukemia Drug resistance Glycoprotein MoAb. |
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