Chlordiazepoxide and stress tolerance in rats |
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| Authors: | P G Henke |
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| Institution: | 1. Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi’an 710032, China;2. Department of Pharmacy, Ninth Hospital of Xi’an, Xi’an, 710054, China;3. Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710049, China;4. Department of Pharmacy, Northwest Women and Children Hospital, Xi’an, 710061 China;5. College of Life Science and Medicine, Northwest University, Xi’an, 710069, China;1. Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran;2. Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran;3. Biotechnology Research Center, Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran |
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| Abstract: | Intraperitoneal injections of chlordiazepoxide in rats attenuated the severity of stomach ulcers induced by a single restraint session. However, when the drug was withheld during the last session of a series of repeated restraint treatments, stomach erosions developed in the animals. Vehicle-controls, on the other hand, had adapted to the chronic stress, as indexed by a decline in gastric pathology. The results were discussed in reference to stress adaptation and drug withdrawal effects. |
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