Agranulocytosis induced by proton pump inhibitors |
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| Authors: | Dury Sandra Nardi Julie Gozalo Claire Lebargy François Deslee Gaëtan |
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| Affiliation: | *Departments of Respiratory Medicine ?Pharmacology and Toxicology, University Hospital of Reims ?Immunology and Microbiology Unit §INSERM UMRS 903, University of Reims, Reims, France. |
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| Abstract: | We report the first published case of agranulocytosis induced by omeprazole and its recurrence with esomeprazole, the S-isomer form of omeprazole. Interestingly, we found an homozygotous mutation of CYP2C19*17, responsible for the metabolism of proton pump inhibitors. |
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