| 晚期糖基化终产物靶向治疗药物与糖尿病血管内皮功能紊乱 |
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| 引用本文： | 张冰,程罡,王莉莉,李松. 晚期糖基化终产物靶向治疗药物与糖尿病血管内皮功能紊乱[J]. 中国药理学通报, 2007, 23(5): 565-567 |
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| 作者姓名： | 张冰 程罡 王莉莉 李松 |
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| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 糖尿病人的低生活质量及高死亡率大都与血管并发症有关。晚期糖基化终产物(AGEs)在糖尿病血管并发症中具有重要作用,其导致的血管内皮细胞功能紊乱是许多血管病变的起因,从而成为引发各种糖尿病并发症的原因之一。研究显示,AGEs抑制剂与裂解剂能够预防或逆转各种糖尿病并发症,这两种药物的研究及应用将为糖尿病血管并发症的治疗提供新的选择。
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| 关 键 词： | 晚期糖基化终产物 内皮细胞 糖尿病 |
| 文章编号： | 1001-1978（2007）05-0565-03 |
| 修稿时间： | 2006-12-05 |
Advanced glycation end products cross-links and diabetic-induced endothelium dysfunction |
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| ZHANG Bing,CHENG Gang,WANG Li-li,LI Song. Advanced glycation end products cross-links and diabetic-induced endothelium dysfunction[J]. Chinese Pharmacological Bulletin, 2007, 23(5): 565-567 |
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| Authors: | ZHANG Bing CHENG Gang WANG Li-li LI Song |
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| Affiliation: | Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences ,Beijing 100850, China |
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| Abstract: | Diabetic vascular complications are the key cause of the poor life quality and high mortality in diabetic patient. Advanced glycation end products (AGEs) and its cross-links play important roles in the diabetic vascular complications. Endothelial cells damage induced by AGEs may account for the initial agent for diabetic vascular complications. Recent studies have shown that AGEs inhibitors and breakers can prevent and reverse these complications. This article reviewed the research progress of AGEs and endothelium dysfunction. The potential therapeutic method was also stated. |
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| Keywords: | advanced glycation end products endothelial cell diabetes mellitus |
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