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| 失敏态烟碱样受体 | |
| 引用本文： | 孙秀兰,胡刚,汪海. 失敏态烟碱样受体[J]. 中国药理学通报, 2003, 19(12): 1321-1325 |
| 作者姓名： | 孙秀兰 胡刚 汪海 |
| 作者单位： | 1. 军事医学科学院毒物药物研究所,北京,100850;南京医科大学药理学与神经生物学系,南京,210029 2. 南京医科大学药理学与神经生物学系,南京,210029 3. 军事医学科学院毒物药物研究所,北京,100850 |
| 基金项目： | 国家自然科学基金资助项目No 30 371 6 41 |
| 摘 要： | 烟碱样受体属于配体门控性离子通道受体 ,参与调节体内许多生理过程。激动剂反复作用可以诱导N受体失敏 ,许多因素参与调节烟碱样受体的失敏 ,如受体亚单位、信号转导系统、细胞微环境的变化等都会影响受体的失敏过程。失敏态N受体并非处于无功能状态 ,它们可能参与调节递质的释放、调节突触可塑性等过程 |
| 关 键 词： | 失敏 烟碱样受体 乙酰胆碱 胆碱 |
| 文章编号： | 1001-1978(2003)12-1321-05 |
| 修稿时间： | 2003-06-23 |
Desensitization of nicotinic receptors |
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| SUN Xiu-Lan ,,HU Gang ,WANG Hai. Desensitization of nicotinic receptors[J]. Chinese Pharmacological Bulletin, 2003, 19(12): 1321-1325 | |
| Authors: | SUN Xiu-Lan HU Gang WANG Hai |
| Affiliation: | SUN Xiu-Lan 1,2,HU Gang 2,WANG Hai 1 |
| Abstract: | Nicotinic acetylcholine receptors, a ligand-gated ion c hannels,mediates many important physiological processes. Chronic nicotine admini stration could desensitize nicotinic receptors. Many factors which modulate dese nsitization have been described, including different subunits, agonist, signal t ransduction and cellular microenivornment. The important physiological functions of desensitized receptors still remain controversial, may be modulate synaptic transmission,synapse plasticity and mediate self-protection. |
| Keywords: | desensitization nicotinic receptor acetylcholine choline |
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