整蛋白型肠内营养剂对老年稳定期慢性阻塞性肺疾病患者营养干预的试验研究

目的 观察整蛋白型肠内营养剂（粉剂）对老年稳定期慢性阻塞性肺疾病（COPD）患者的营养干预作用.方法 选择老年稳定期COPD患者60例,按余数随机分组法分为对照组和能全素组,每组30例,2组均给予常规口服药物及氧疗,均衡饮食,能全素组每日另服用整蛋白型肠内营养剂（粉剂）160 g,共12周.实验前后对患者均进行圣乔治呼吸问卷（SGRQ）评估、人体测量、营养状况评估、6 min步行距离及肺功能检测.结果 经过营养支持治疗,能全素组患者的一般情况,如体质量（48.7±1.4）kg、肱三头肌皮褶厚度（7.5±1.6）mm、血清白蛋白（39±5） mg/L等明显优于对照组体质量（48.4±2.5）kg、肱三头肌皮褶厚度（6.8±2.0） mm、血清白蛋白（36 ±4） mg/L（P ＜0.05）];SGRQ评分能全素组治疗后（43.8±2.1）分与对照组治疗后（45.0±2.0）分相比较差异有统计学意义（P ＜0.05）;6 min步行试验能全素组治疗后（39±7）m与对照组治疗后的（31 ±7）m,比较差异有统计学意义（P＜0.05）;第1秒钟用力呼气容积/预计值（％）能全素组治疗后为（69±7）％,与对照组治疗后（62±6）％]比较差异有统计学意义（P＜0.05）;血清免疫球蛋白含量能全素组治疗后IgA,IgG,IgM与对照组治疗后比较IgA：（l.9±1.1）g/L比（1.7±0.8）g/L,IgG（10.0±1.9）g/L比（9.1±1.5）g/L,IgM（1.2±0.5）g/L比（0.9±0.5）g/L]差异无统计学意义（P＞0.05）.结论 老年稳定期COPD患者坚持口服整蛋白型肠内营养剂（粉剂）,可改善患者的营养状况、健康状况及呼吸功能.

Intacted protein enteral nutrition powder on senile patients with stable chronic obstructive pulmonary diseases

Objective To investigate the effects of intacted protein enteral nutrition powder on senile patients with stable chronic obstructive pulmonary diseases （COPD）.Methods The 60 cases were randomly divided into 2 groups：control group and Nutrition group.Oxygen therapy was applied with a balanced diet.Nutrison group was given nutrison 160g daily for 12 weeks.The outcomes were compared according to the St.George＇s respiratory questionnaire（SGRQ）,somatometric measurement,6 minutes walking test and lung function tests.Results After the nutritional support treatment,pationts＇ general state of health in the nutrition group was obviously better than that in the control group,including body weight,triceps skinfold thickness and serum-albumin （48.7 ± 1.4）kg vs （48.4 ±2.5）kg,（7.5 ± 1.6）mm vs （6.8 ±2.0）mm,（39 ±5）mg/L vs （36 ±4）mg/L]（P 〈 0.05）.Compared to the control group,the scores of SGRQ.somatometric measurement,6 minutes walking distance and lung function tests in nutrition group were also higher（43.8 ± 2.1）scores vs.（45.0 ± 2.0）scores,（39 ± 7） m vs.（31 ± 7） m,（69 ± 7） % vs （62 ± 6） %] （P 〈 0.05）,but the level of serum immune globulin was not differentIgA （1.9±1.1）g/Lvs.（1.7±0.8）g/L,IgG （10.0±1.9）g/Lvs.（9.1 ±1.5）g/L,IgM （1.2±0.5）g/L vs.（0.9±0.5）g/L] （P〉0.05）.Conclusion The nutritional state,health status and respiratory function can be improved if senile patients with stable COPD take nutrition therapy.