盐酸氨酮戊酸光动力疗法联合多功能电离子治疗仪治疗尖锐湿疣的疗效观察

目的 评价盐酸氨酮戊酸光动力疗法（ALA-PDT）联合多功能电离子治疗仪治疗尖锐湿疣的疗效和复发率.方法 将60例尖锐湿疣患者按治疗方法不同分为联合治疗组（采用ALA-PDT联合多功能电离子治疗仪治疗）和对照组（单用多功能电离子治疗仪治疗）,每组30例.均为每周1次,疗程不超过3周.观察不良反应,于末次治疗后1周判定疗效,末次治疗后1个月、6个月观察复发情况.结果 联合治疗组和对照组痊愈率分别为80.00％（24/30）和96.67％（29/30）,两组比较差异无统计学意义（P＞0.05）;联合治疗组治疗后1个月、6个月复发率分别为8.33％（2/24）,12.50％（3/24）,对照组分别为17.24％（5/29）,41.38％（12/29）,两组治疗后1个月复发率比较差异无统计学意义（χ^2=0.298,P＞0.05）.两组治疗后6个月复发率比较差异有统计学意义（χ^2=4.030,P＜0.05）.两组均无系统不良反应,联合治疗组发生不良反应16例次,对照组为44例次.结论 ALA-PDT联合多功能电离子治疗仪治疗尖锐湿疣痊愈率高,复发率低,不良反应少.

Efficacy of aminolevulinic acid hydrochloride photodynamic therapy combined with multi-function electronic therapeutic device in the treatment of condyloma acuminatum

Objective To evaluate the efficacy of aminolevulinic acid hydrochloride photodynamic therapy （ALA-PDT） combined with multi-function electronic therapeutic device in the treatment of condyloma acuminatum.Methods Sixty cases with condyloma acuminatum were divided into two groups with 30 cases each according to the treatment method.The combination group was treated with ALA-PDT combined with multi-function electronic therapeutic device,and the control group was treated only with multi-function electronic therapeutic device.Once a week,treatment was not more than three weeks.The adverse reaction was observed.The efficacy was evaluated after 1 week＇s treatment.The recurrence rate was evaluated after 1,6 months＇ s treatment.Results The cure rate was 80.00% （24/30） and 96.67% （29/30） in combination group and control group,and there was no significant difference （P 〉 0.05）.The recurrence rate was 8.33% （2/24）,12.50%（3/24） in combination group and 17.24% （5/29）,41.38% （12/29） in control group after 1,6 months＇s treatment,and there was no significant difference after 1 month＇s treatment （χ^2 =0.298,P 〉 0.05）,but there was significant difference after 6 months＇ s treatment （χ^2 =4.030,P 〈 0.05）.There was no system adverse reaction,the adverse reaction was 16 cases in combination group and 44 cases in control group.Conclusion ALA-PDT combined with multi-function electronic therapeutic device in the treatment of condyloma acuminatum can improve the cure rate,decrease the recurrence rate and adverse reaction.